Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.64 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.45 |
| ▸ | DHFR | P00374 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7568234 | 0.80 | PBRM1 (0.69) | PBRM1DHFRKDM4EALDH1A1 | |
| SCHEMBL2440948 | 0.80 | PBRM1 (0.69) | PBRM1ABCG2DHFRKDM4E | |
| SCHEMBL7564762 | 0.80 | PBRM1 (0.69) | PBRM1DHFRKDM4E | |
| SCHEMBL7567087 | 0.80 | PBRM1 (0.64) | PBRM1GABRA1ABCG2DHFRKDM4E | |
| SCHEMBL8789035 | 0.80 | PBRM1 (0.64) | PBRM1ABCG2DHFRKDM4ENPC1 | |
| SCHEMBL7565942 | 0.80 | PBRM1 (0.64) | PBRM1ABCG2DHFRKDM4ENPC1 | |
| SCHEMBL8789976 | 0.80 | PBRM1 (0.64) | PBRM1ABCG2KDM4EALDH1A1 | |
| SCHEMBL7570750 | 0.79 | PBRM1 (0.72) | PBRM1DHFRKDM4ENPC1 | |
| SCHEMBL4943278 | 0.79 | PBRM1 (1.00) | PBRM1ABCG2DHFRKDM4EALDH1A1 | |
| SCHEMBL29801740 | 0.79 | PBRM1 (1.00) | PBRM1ABCG2DHFRKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934278-B1 | BIS(ACRIDINECARBOXAMIDE) AND BIS(PHENAZINECARBOXAMIDE) AS ANTITUMOUR AGENTS | XENOVA LTD (GB) | 2002-09-04 | — | — | EP | disclosed |
| US-6114332-A | BACTERICIDES | XENOVA LIMITED (GB) | 2000-09-05 | — | — | US | disclosed |
| EP-0934278-A1 | BIS(ACRIDINECARBOXAMIDE) AND BIS(PHENAZINECARBOXAMIDE) AS ANTITUMOUR AGENTS | XENOVA LIMITED (GB) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998017650-A1 | BIS(ACRIDINECARBOXAMIDE) AND BIS(PHENAZINECARBOXAMIDE) AS ANTITUMOUR AGENTS | XENOVA LIMITED (GB) | 1998-04-30 | — | — | WO | disclosed |