Sugi Predict

Sugi Predict / Compounds / SCHEMBL7567464

SCHEMBL7567464

SCHEMBL7567464

O=C(NN=Cc1ccc([N+](=O)[O-])cc1)c1[nH]c2ccc(Br)cc2c1-c1ccccc1

nearest known ligand 0.80

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 12/20 0.80
▸ LMNA P02545 6/20 0.80
▸ MEN1 O00255 9/20 0.78
▸ KMT2A Q03164 9/20 0.78
▸ ALDH1A1 P00352 7/20 0.78
▸ KDM4E B2RXH2 6/20 0.78
▸ PAX8 Q06710 2/20 0.78
▸ SMN1; SMN2 Q16637 4/20 0.73
▸ RAB9A P51151 3/20 0.73
▸ HPGD P15428 2/20 0.73
▸ POLB P06746 3/20 0.68
▸ TP53 P04637 1/20 0.68
▸ MAPK1 P28482 2/20 0.65
▸ TDP1 Q9NUW8 1/20 0.65
▸ NPC1 O15118 2/20 0.59
▸ TUBB4A P04350 2/20 0.57
▸ TUBB P07437 2/20 0.57
▸ TUBA3C P0DPH7 2/20 0.57
▸ TUBA1B P68363 2/20 0.57
▸ TUBA4A P68366 2/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7567457 1.00 MAPT (0.80) MAPTLMNAMEN1KMT2AALDH1A1
SCHEMBL7560228 0.90 MAPT (0.94) MAPTLMNAMEN1KMT2AALDH1A1
SCHEMBL7534796 0.90 MAPT (0.94) MAPTLMNAMEN1KMT2AALDH1A1
SCHEMBL7560112 0.89 MAPT (1.00) MAPTLMNAMEN1KMT2AALDH1A1
SCHEMBL7560116 0.89 MAPT (1.00) MAPTLMNAMEN1KMT2AALDH1A1
SCHEMBL12136736 0.89 TUBB4A (0.73) MAPTLMNAMEN1KMT2AALDH1A1
SCHEMBL7561118 0.89 MAPT (0.65) MAPTLMNAMEN1KMT2AALDH1A1
SCHEMBL7561111 0.89 MAPT (0.65) MAPTLMNAMEN1KMT2AALDH1A1
SCHEMBL7561883 0.87 MAPT (0.86) MAPTLMNAMEN1KMT2AALDH1A1
SCHEMBL7561885 0.87 MAPT (0.86) MAPTLMNAMEN1KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20020091148-A1 3-substituted indole antiproliferative angiogenesis inhibitors ABBOTT LABORATORIES 2002-07-11 — — US claimed
WO-2002022576-A2 3-SUBSTITUTED INDOLE CARBOHYDRAZIDES USEFUL AS CELL PROLIFERATION AND ANGIOGENESIS INHIBITORS ABBOTT LABORATORIES (US) 2002-03-21 — — WO claimed
US-20020091148-A1 3-substituted indole antiproliferative angiogenesis inhibitors ABBOTT LABORATORIES 2002-07-11 — — US disclosed
WO-2002022576-A2 3-SUBSTITUTED INDOLE CARBOHYDRAZIDES USEFUL AS CELL PROLIFERATION AND ANGIOGENESIS INHIBITORS ABBOTT LABORATORIES (US) 2002-03-21 — — WO disclosed
US-6323228-B1 INHIBITING ANGIOGENESIS IN A MAMMAL IN RECOGNIZED NEED OF SUCH TREATMENT COMPRISING ADMINISTERING TO THE MAMMAL WITH INDOLE SUBSTITUTED WITH HYDRAZIDES ABBOTT LABORATORIES 2001-11-27 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020091148-A1 3-substituted indole antiproliferative angiogenesis inhibitors MKI67, FLT4, IDO1 MAPT 4828/4885LMNA 4535/4885MEN1 3165/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.