Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 17/20 | 0.58 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4671200 | 0.84 | HTR6 (0.61) | HTR6CYP3A4CYP2D6 | |
| SCHEMBL3338517 | 0.77 | HTR6 (0.51) | HTR6 | |
| SCHEMBL4673875 | 0.74 | HTR6 (1.00) | HTR6CYP3A4CYP2D6 | |
| SCHEMBL4676436 | 0.71 | HTR6 (1.00) | HTR6DRD2CYP3A4CYP2D6 | |
| SCHEMBL4674305 | 0.70 | HTR6 (0.82) | HTR6CYP3A4CYP2D6 | |
| SCHEMBL7485051 | 0.69 | HTR6 (0.79) | HTR6 | |
| SCHEMBL4671281 | 0.69 | HTR6 (0.76) | HTR6CYP3A4CYP2D6 | |
| SCHEMBL4670653 | 0.68 | HTR6 (0.80) | HTR6 | |
| SCHEMBL3335540 | 0.68 | HTR6 (0.80) | HTR6DRD2CYP3A4CYP2D6 | |
| SCHEMBL4671653 | 0.67 | HTR6 (0.76) | HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173432-A1 | PIPERIDINE-INDOLE COMPOUNDS HAVING 5-HT6 AFFINITY | NPS Allelix Corp. (CA) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000063203-A1 | PIPERIDINE-INDOLE COMPOUNDS HAVING 5-HT6 AFFINITY | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 2000-10-26 | — | — | WO | disclosed |