Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 11/20 | 0.54 |
| ▸ | CTSS | P25774 | 4/20 | 0.47 |
| ▸ | CTSK | P43235 | 3/20 | 0.47 |
| ▸ | CTSB | P07858 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | CTSV | O60911 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5534377 | 0.89 | CTSL (0.49) | CTSLCTSSCTSKCTSBGAA | |
| SCHEMBL5528527 | 0.88 | CTSL (0.48) | CTSLCTSSCTSKCTSBGAA | |
| SCHEMBL7562354 | 0.88 | CTSL (0.48) | CTSLCTSSCTSKCTSBGAA | |
| SCHEMBL5526266 | 0.88 | CTSL (0.53) | CTSLCTSSCTSKCTSBHPGD | |
| SCHEMBL5525342 | 0.88 | CTSL (0.60) | CTSLCTSSCTSKCTSBCYP1A2 | |
| SCHEMBL6592939 | 0.88 | CTSL (0.47) | CTSLCTSSCTSKCTSBGAA | |
| SCHEMBL5520691 | 0.88 | CTSL (0.50) | CTSLCTSSCTSKCTSBCYP1A2 | |
| SCHEMBL5522783 | 0.88 | CTSL (0.53) | CTSLCTSSCTSKCTSBGRM5 | |
| SCHEMBL5522994 | 0.88 | CTSL (0.47) | CTSLCTSSCTSKCTSBGAA | |
| SCHEMBL5523614 | 0.88 | MEN1 (0.54) | CTSLCTSSCTSKCTSBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1178958-A2 | N-CYANOMETHYL AMIDES AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2002-02-13 | — | — | EP | disclosed |
| WO-2000055125-A2 | N-CYANOMETHYL AMIDES AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2000-09-21 | — | — | WO | disclosed |