Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.38 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7573714 | 0.90 | TSHR (0.42) | EDNRBMAPTLMNATSHRTP53 | |
| SCHEMBL7566550 | 0.90 | EDNRB (0.60) | EDNRBMAPTLMNASMN1; SMN2NPC1 | |
| SCHEMBL7570806 | 0.84 | TP53 (0.39) | MAPTTSHRTP53ALDH1A1GAA | |
| SCHEMBL7569202 | 0.80 | EDNRB (0.70) | EDNRBMAPTLMNASMN1; SMN2NPC1 | |
| SCHEMBL7568104 | 0.79 | EDNRB (0.57) | EDNRBMAPTLMNASMN1; SMN2NPC1 | |
| SCHEMBL7570877 | 0.78 | EDNRB (0.46) | EDNRBMAPTTP53ALDH1A1GAA | |
| SCHEMBL7568255 | 0.77 | EDNRB (0.65) | EDNRBMAPTLMNASMN1; SMN2TP53 | |
| SCHEMBL7568095 | 0.77 | EDNRB (0.81) | EDNRBMAPTLMNASMN1; SMN2NPC1 | |
| SCHEMBL7573709 | 0.70 | EDNRB (0.46) | EDNRBSMN1; SMN2TSHRALDH1A1MAPK1 | |
| SCHEMBL7566571 | 0.70 | EDNRB (0.56) | EDNRBMAPTLMNASMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799206-B1 | ARYL- AND HETARYL-SULFONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ENDOTHELIN ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2002-09-11 | — | — | EP | claimed |