Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | FABP4 | P15090 | 3/20 | 0.38 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.36 |
| ▸ | SLC16A3 | O15427 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.34 |
| ▸ | CPT2 | P23786 | 1/20 | 0.34 |
| ▸ | CPT1A | P50416 | 1/20 | 0.34 |
| ▸ | ACLY | P53396 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7568104 | 0.92 | EDNRB (0.57) | EDNRBTSHRMAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7570801 | 0.89 | EDNRB (0.42) | EDNRBTSHRMAPK1ALDH1A1ACLY | |
| SCHEMBL7566571 | 0.85 | EDNRB (0.56) | EDNRBTSHRMAPK1SLC16A3ALDH1A1 | |
| SCHEMBL7567636 | 0.83 | EDNRB (0.52) | EDNRB | |
| SCHEMBL7567507 | 0.81 | EDNRB (0.66) | EDNRBTSHRMAPK1SLC16A3ALDH1A1 | |
| SCHEMBL7569419 | 0.78 | EDNRB (0.54) | EDNRBTSHRMAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7569202 | 0.78 | EDNRB (0.70) | EDNRBALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL7565566 | 0.77 | EDNRB (0.51) | EDNRB | |
| SCHEMBL8771691 | 0.77 | EDNRB (0.49) | EDNRBMAPK1ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL7568255 | 0.76 | EDNRB (0.65) | EDNRBALDH1A1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799206-B1 | ARYL- AND HETARYL-SULFONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ENDOTHELIN ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2002-09-11 | — | — | EP | claimed |