Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 4/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | FNTA | P49354 | 10/20 | 0.43 |
| ▸ | FNTB | P49356 | 10/20 | 0.43 |
| ▸ | PGGT1B | P53609 | 9/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7137318 | 0.85 | SLC6A2 (0.36) | CYP19A1FNTAFNTBPGGT1B | |
| SCHEMBL7572062 | 0.81 | CYP11B1 (0.47) | CYP11B1CYP11B2CYP19A1FNTAFNTB | |
| SCHEMBL7567592 | 0.80 | CYP11B1 (0.46) | CYP11B1CYP11B2CYP19A1FNTAFNTB | |
| SCHEMBL5098757 | 0.70 | FNTA (0.50) | FNTAFNTBPGGT1B | |
| SCHEMBL5099434 | 0.70 | FNTA (0.50) | FNTAFNTBPGGT1B | |
| SCHEMBL5088977 | 0.70 | FNTA (0.50) | FNTAFNTBPGGT1B | |
| Hydrochloric Acid SCHEMBL7048952 | 0.69 | FNTA (0.49) | FNTAFNTBPGGT1B | |
| Hydrochloric Acid SCHEMBL7577063 | 0.68 | FNTA (0.66) | FNTAFNTBPGGT1B | |
| Hydrochloric Acid SCHEMBL7571150 | 0.66 | FNTA (0.69) | FNTAFNTBPGGT1B | |
| SCHEMBL7049602 | 0.65 | CYP11B1 (0.48) | CYP11B1CYP11B2CYP19A1FNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020019527-A1 | Substituted phenyl farnesyltransferase inhibitors | ABBOTT LABORATORIES | 2002-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020019527-A1 | Substituted phenyl farnesyltransferase inhibitors | FNTA, FNTB, SLC10A1 | CYP11B1 94/4885CYP11B2 203/4885CYP19A1 589/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.