Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 4/20 | 0.38 |
| ▸ | AVPR1A | P37288 | 4/20 | 0.38 |
| ▸ | AVPR1B | P47901 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7476174 | 0.97 | AVPR2 (0.38) | AVPR2AVPR1AAVPR1BALDH1A1POLB | |
| SCHEMBL7966328 | 0.95 | AVPR2 (0.36) | AVPR2AVPR1AAVPR1BALDH1A1LMNA | |
| SCHEMBL7954752 | 0.95 | AVPR2 (0.39) | AVPR2AVPR1AAVPR1BALDH1A1POLB | |
| SCHEMBL7483216 | 0.92 | AVPR2 (0.38) | AVPR2AVPR1AAVPR1BMAP3K7BRD4 | |
| Hydrochloric Acid SCHEMBL7485435 | 0.91 | AVPR2 (0.36) | AVPR2AVPR1AAVPR1BMAP3K7BRD4 | |
| Hydrochloric Acid SCHEMBL7963173 | 0.91 | AVPR2 (0.38) | AVPR2AVPR1AAVPR1BMAP3K7BRD4 | |
| SCHEMBL7953928 | 0.91 | AVPR2 (0.37) | AVPR2AVPR1AAVPR1BMAP3K7BRD4 | |
| SCHEMBL7972260 | 0.91 | AVPR2 (0.35) | AVPR2AVPR1AAVPR1BALDH1A1POLB | |
| SCHEMBL7972243 | 0.91 | AVPR2 (0.37) | AVPR2AVPR1AAVPR1BMAP3K7BRD4 | |
| Hydrochloric Acid SCHEMBL7964657 | 0.91 | AVPR2 (0.37) | AVPR2AVPR1AAVPR1BMAP3K7BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316482-B1 | FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |
| US-6207693-B1 | Benzamide derivatives having a vasopressin antagonistic activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |
| EP-0946519-A1 | BENZAMIDE DERIVATIVES HAVING A VASOPRESSIN ANTAGONISTIC ACTIVITY | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998024771-A1 | BENZAMIDE DERIVATIVES HAVING A VASOPRESSIN ANTAGONISTIC ACTIVITY | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-06-11 | — | — | WO | disclosed |