Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 4/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 8/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | TSHR | P16473 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5385723 | 0.87 | FFAR1 (0.40) | PPARGFFAR1MAPTALDH1A1TSHR | |
| SCHEMBL7571072 | 0.86 | FFAR1 (0.53) | PPARGFFAR1MAPTPOLBTP53 | |
| SCHEMBL5397282 | 0.86 | FFAR1 (0.45) | PPARGFFAR1MAPTHSD17B10SMN1; SMN2 | |
| SCHEMBL5374488 | 0.86 | FFAR1 (0.39) | PPARGFFAR1MAPTALDH1A1TSHR | |
| SCHEMBL4850044 | 0.85 | KDR (0.43) | PPARGFFAR1MAPTHSD17B10SMN1; SMN2 | |
| SCHEMBL4851267 | 0.85 | FFAR1 (0.46) | PPARGFFAR1MAPTHSD17B10SMN1; SMN2 | |
| SCHEMBL4851874 | 0.84 | FFAR1 (0.41) | PPARGFFAR1MAPTALDH1A1HSD17B10 | |
| SCHEMBL5381940 | 0.83 | FFAR1 (0.41) | PPARGFFAR1ADORA2APPARAADORA3 | |
| SCHEMBL6593504 | 0.83 | FFAR1 (0.42) | PPARGFFAR1SMN1; SMN2ADORA2APKM | |
| SCHEMBL6593508 | 0.83 | FFAR1 (0.42) | PPARGFFAR1SMN1; SMN2ADORA2APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228067-A1 | 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGYLCEMIC AND HYPOLIPIDEMIC ACTIVITY | Takeda Chemical Industries, Ltd. (JP) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001038325-A1 | 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-31 | — | — | WO | disclosed |