Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 3/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.59 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.59 |
| ▸ | CA4 | P22748 | 3/20 | 0.53 |
| ▸ | CA1 | P00915 | 4/20 | 0.53 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL351829 | 1.00 | HDAC3 (0.59) | HDAC3HDAC1HDAC2HDAC8FFAR3 | |
| Succinic Acid SCHEMBL3413315 | 1.00 | HDAC3 (0.59) | HDAC3HDAC1HDAC2HDAC8FFAR3 | |
| Succinic Acid SCHEMBL7759484 | 1.00 | HDAC3 (0.59) | HDAC3HDAC1HDAC2HDAC8FFAR3 | |
| Succinic Acid SCHEMBL9639572 | 1.00 | HDAC3 (0.59) | HDAC3HDAC1HDAC2HDAC8FFAR3 | |
| Succinic Acid SCHEMBL3012461 | 0.96 | HDAC3 (0.62) | HDAC3HDAC1HDAC2HDAC8FFAR3 | |
| Succinic Acid SCHEMBL24440 | 0.96 | HDAC3 (0.62) | HDAC3HDAC1HDAC2HDAC8FFAR3 | |
| Succinic Acid SCHEMBL11211761 | 0.92 | HDAC3 (0.59) | HDAC3HDAC1HDAC2HDAC8FFAR3 | |
| Succinic Acid SCHEMBL2353390 | 0.92 | FFAR3 (0.53) | HDAC3HDAC1HDAC2HDAC8FFAR3 | |
| Succinic Acid SCHEMBL8441137 | 0.92 | HDAC3 (0.59) | HDAC3HDAC1HDAC2HDAC8FFAR3 | |
| Succinic Acid SCHEMBL504448 | 0.92 | FFAR3 (0.53) | HDAC3HDAC1HDAC2HDAC8FFAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106474495-B | Imido- oxalic acid99mThe rgd peptide cancer diagnosis drug and preparation method thereof of Tc label | 中国医学科学院阜外医院 | 2019-07-09 | — | — | CN | claimed |
| CN-113943456-A | Resin composition and multilayer structure using same | 三菱化学株式会社 | 2022-01-18 | — | — | CN | disclosed |
| CN-107532005-B9 | Resin composition and multilayer structure using same | 三菱化学株式会社 | 2022-01-07 | — | — | CN | disclosed |
| CN-107532005-B | Resin composition and multilayer structure using same | 三菱化学株式会社 | 2021-11-12 | — | — | CN | disclosed |
| EP-3281986-B1 | RESIN COMPOSITION AND MULTILAYER STRUCTURE USING SAME | MITSUBISHI CHEM CORP (JP) | 2021-07-21 | — | — | EP | disclosed |
| EP-3281980-B1 | RESIN COMPOSITION AND MULTILAYER STRUCTURE USING SAME, AND METHOD OF IMPROVING LONG-RUN STABILITY | MITSUBISHI CHEM CORP (JP) | 2021-03-03 | — | — | EP | disclosed |
| EP-3056538-B1 | SAPONIFIED ETHYLENE-VINYL ESTER COPOLYMER COMPOSITION, AND MULTILAYER STRUCTURE USING SAID COMPOSITION | MITSUBISHI CHEM CORP (JP) | 2020-12-02 | — | — | EP | disclosed |
| US-10611894-B2 | Resin composition and multilayer structure using same, and method of improving long-run stability | MITSUBISHI CHEMICAL CORPORATION (JP) | 2020-04-07 | — | — | US | disclosed |
| US-10427389-B2 | Resin composition and multilayer structure using same | MITSUBISHI CHEMICAL CORPORATION (JP) | 2019-10-01 | — | — | US | disclosed |
| CN-106474495-B | Imido- oxalic acid99mThe rgd peptide cancer diagnosis drug and preparation method thereof of Tc label | 中国医学科学院阜外医院 | 2019-07-09 | — | — | CN | disclosed |
| CN-103641758-A | Cheap preparation method for high purity D,L-methionine | CHONGQING UNISPLENDOUR CHEM CO | 2014-03-19 | — | — | CN | disclosed |
| CN-103641759-A | Environmentally-friendly preparation method of highly-pure D,L-2-hydroxy-4-methylthiobutyramide | CHONGQING UNISPLENDOUR CHEM CO | 2014-03-19 | — | — | CN | disclosed |
| CN-103641755-A | Preparation method of D,L-2-hydroxy-4-methylthiobutyric acid-trace element chelate | CHONGQING UNISPLENDOUR CHEM CO | 2014-03-19 | — | — | CN | disclosed |
| CN-103524388-A | Preparation method of D,L-2-hydroxy-4-methylthiobutyrate | CHONGQING UNISPLENDOUR CHEM CO | 2014-01-22 | — | — | CN | disclosed |
| CN-103497131-A | Preparation method of 2-hydroxy-4-methylthio butyric acid metal chelate | CHONGQING UNISPLENDOUR CHEM CO | 2014-01-08 | — | — | CN | disclosed |
| CN-103467348-A | Preparation method of large-particle crystal type high-bulk-density calcium 2-hydroxy-4-(methylthio)butyrate | CHONGQING UNISPLENDOUR CHEM CO | 2013-12-25 | — | — | CN | disclosed |
| CN-103420883-A | Method for using crude hydrocyanic acid gas for preparing 2-hydroxy-4-methylmercapto-butyronitrile | CHONGQING UNISPLENDOUR CHEM CO | 2013-12-04 | — | — | CN | disclosed |
| US-20020045027-A1 | Anti-fog resin sheet, anti-fog agent and method article | DAINIPPON INK AND CHEMICALS, INC. (JP) | 2002-04-18 | — | — | US | disclosed |
| CN-1340587-A | Antifogging resin sheet, antifogging agent and molded article | DAINIPPON INK & CHEMICALS (JP) | 2002-03-20 | — | — | CN | disclosed |
| EP-1184408-A2 | Anti-fog resin sheet, anti-fog agent and molded article | DAINIPPON INK AND CHEMICALS, INC. (JP) | 2002-03-06 | — | — | EP | disclosed |