Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 2/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.53 |
| ▸ | CA4 | P22748 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 3/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | BBOX1 | O75936 | 5/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL29586668 | 1.00 | FFAR3 (0.53) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Succinic Acid SCHEMBL156757 | 0.96 | — | — | |
| Succinic Acid SCHEMBL30712481 | 0.96 | FFAR3 (0.56) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Succinic Acid SCHEMBL3862916 | 0.92 | FFAR3 (0.53) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Succinic Acid SCHEMBL19704478 | 0.92 | FFAR3 (0.53) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Succinic Acid SCHEMBL2349922 | 0.92 | FFAR3 (0.53) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Succinic Acid SCHEMBL7759484 | 0.92 | HDAC3 (0.59) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Succinic Acid SCHEMBL7569477 | 0.92 | HDAC3 (0.59) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Succinic Acid SCHEMBL63118 | 0.92 | HDAC3 (0.59) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Succinic Acid SCHEMBL351829 | 0.92 | HDAC3 (0.59) | FFAR3HDAC3HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11213542-B2 | Method and agent for lowering total cholesterol levels and for improving blood lipid spectrum composition | BIOGIX, INC. (US) | 2022-01-04 | — | — | US | disclosed |
| US-20210161940-A1 | Method and agent for lowering total cholesterol levels and for improving blood lipid spectrum composition | BANK OF SCOTLAND PLC (GB) | 2021-06-03 | — | — | US | disclosed |
| US-9926578-B2 | Process for manufacturing butanediol | PURAC BIOCHEM BV (NL) | 2018-03-27 | — | — | US | disclosed |
| US-20160040194-A1 | Process for manufacturing butanediol | PURAC BIOCHEM BV (NL) | 2016-02-11 | — | — | US | disclosed |
| US-9216184-B1 | Agent and method for increasing testosterone level in a body | Lunada Biomedical, LLC (US) | 2015-12-22 | — | — | US | disclosed |
| US-9162961-B2 | Process for manufacturing succinic acid | PURAC BIOCHEM BV (NL) | 2015-10-20 | — | — | US | disclosed |
| CN-104321298-A | Recovery of Carboxylic Acids from Magnesium Carboxylate Mixtures | PURAC BIOCHEM BV | 2015-01-28 | — | — | CN | disclosed |
| CN-102753514-B | Process for manufacturing succinic acid | PURAC BIOCHEM BV | 2014-11-26 | — | — | CN | disclosed |
| EP-2360137-B1 | Process for manufacturing succinic acid | PURAC BIOCHEM BV (NL) | 2013-08-07 | — | — | EP | disclosed |
| US-20120316368-A1 | PROCESS FOR MANUFACTURING SUCCINIC ACID | PURAC BIOCHEM BV (NL) | 2012-12-13 | — | — | US | disclosed |
| CN-102753514-A | Process for manufacturing succinic acid | PURAC BIOCHEM BV | 2012-10-24 | — | — | CN | disclosed |
| EP-2360137-A1 | Process for manufacturing succinic acid | PURAC Biochem BV (NL) | 2011-08-24 | — | — | EP | disclosed |