Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.39 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31361988 | 0.89 | ALDH1A1 (0.53) | SMN1; SMN2L3MBTL1ALDH1A1POLBTDP1 | |
| SCHEMBL4975136 | 0.89 | ALDH1A1 (0.53) | SMN1; SMN2L3MBTL1ALDH1A1POLBTDP1 | |
| Hydrochloric Acid SCHEMBL6946304 | 0.88 | ALDH1A1 (0.57) | SMN1; SMN2L3MBTL1ALDH1A1POLBTDP1 | |
| Bromide SCHEMBL29203650 | 0.88 | POLB (0.52) | SMN1; SMN2L3MBTL1ALDH1A1POLBTDP1 | |
| SCHEMBL1976303 | 0.84 | IDO1 (0.44) | L3MBTL1ALDH1A1KMT2AGAAKDM4E | |
| Hydrochloric Acid SCHEMBL29155176 | 0.82 | IDO1 (0.42) | L3MBTL1ALDH1A1KMT2AGAAKDM4E | |
| Bromide SCHEMBL29155172 | 0.82 | IDO1 (0.42) | L3MBTL1ALDH1A1KMT2AGAAKDM4E | |
| Acetic Acid SCHEMBL10562638 | 0.80 | POLB (0.52) | SMN1; SMN2ALDH1A1POLBMAPK1KMT2A | |
| SCHEMBL30893041 | 0.76 | CACNA1C (0.40) | SMN1; SMN2L3MBTL1POLBMAPK1GAA | |
| SCHEMBL6236003 | 0.75 | POLB (0.50) | L3MBTL1ALDH1A1POLBTDP1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144399-A3 | HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING A SUBSTITUTED PHENYLENEDIAMINE GROUP | Wyeth (US) | 2002-09-11 | — | — | EP | disclosed |
| EP-1144399-A2 | HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING A SUBSTITUTED PHENYLENEDIAMINE GROUP | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000034261-A2 | HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING A SUBSTITUTED PHENYLENEDIAMINE GROUP | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-06-15 | — | — | WO | disclosed |