Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.60 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.56 |
| ▸ | CFTR | P13569 | 5/20 | 0.54 |
| ▸ | PRKCI | P41743 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.46 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL399749 | 0.83 | CFTR (0.80) | CFTRIKBKETBK1 | |
| SCHEMBL857524 | 0.81 | ROCK1 (0.67) | ADORA2AROCK1CFTRPRKCIKMT2A | |
| SCHEMBL2638921 | 0.81 | ADORA2A (0.70) | ADORA2AROCK1KMT2AMAP2K1 | |
| SCHEMBL11883907 | 0.80 | MAP2K1 (0.61) | ADORA2AROCK1KMT2AMAP2K1 | |
| SCHEMBL2114977 | 0.79 | ADORA2A (0.67) | ADORA2AROCK1KMT2AMAP2K1 | |
| SCHEMBL9688965 | 0.79 | ADORA2A (0.57) | ADORA2AROCK1CFTRKMT2AMAP2K1 | |
| Hydrochloric Acid SCHEMBL10655021 | 0.77 | ADORA2A (0.65) | ADORA2AROCK1KMT2AMAP2K1 | |
| SCHEMBL1820660 | 0.77 | ADORA2A (0.61) | ADORA2AROCK1KMT2AMAP2K1 | |
| SCHEMBL12496363 | 0.77 | ADORA2A (0.73) | ADORA2AMAP2K1 | |
| SCHEMBL29753973 | 0.75 | CFTR (0.63) | ROCK1CFTRKMT2AIKBKETBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958297-A1 | 1-ARYL-1,8-NAPHTHYLIDIN-4-ONE DERIVATIVE AS TYPE IV PHOSPHODIESTERASE INHIBITOR | SUNTORY LIMITED (JP) | 1999-11-24 | — | — | EP | disclosed |
| WO-1999007704-A1 | 1-ARYL-1,8-NAPHTHYLIDIN-4-ONE DERIVATIVE AS TYPE IV PHOSPHODIESTERASE INHIBITOR | SUNTORY LIMITED (JP) | 1999-02-18 | — | — | WO | disclosed |