Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 6/20 | 0.57 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.47 |
| ▸ | CFTR | P13569 | 3/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8053479 | 0.84 | CFTR (0.62) | CFTR | |
| SCHEMBL7569893 | 0.79 | ADORA2A (0.60) | ADORA2AROCK1MAP2K1CFTRKMT2A | |
| SCHEMBL2638921 | 0.78 | ADORA2A (0.70) | ADORA2AROCK1MAP2K1CNR2CAMKK2 | |
| SCHEMBL22130444 | 0.77 | NPC1 (0.54) | CFTRKMT2A | |
| SCHEMBL2114977 | 0.76 | ADORA2A (0.67) | ADORA2AROCK1MAP2K1CNR2CAMKK2 | |
| SCHEMBL11883907 | 0.74 | MAP2K1 (0.61) | ADORA2AROCK1MAP2K1CNR2CAMKK2 | |
| SCHEMBL1820660 | 0.74 | ADORA2A (0.61) | ADORA2AROCK1MAP2K1CNR2CAMKK2 | |
| Hydrochloric Acid SCHEMBL10655021 | 0.74 | ADORA2A (0.65) | ADORA2AROCK1MAP2K1CNR2CAMKK2 | |
| SCHEMBL12496363 | 0.74 | ADORA2A (0.73) | ADORA2AMAP2K1CNR2ADORA1 | |
| SCHEMBL11415277 | 0.74 | CFTR (0.37) | ADORA2ACFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0298134-B1 | AROMATIC HETEROCYCLIC CARBOXYLIC ACID AMIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | Dainippon Pharmaceutical Co., Ltd. (JP) | 1992-11-11 | — | — | EP | disclosed |
| US-4965266-A | Antiallergens | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1990-10-23 | — | — | US | disclosed |
| EP-0298134-A1 | AROMATIC HETEROCYCLIC CARBOXYLIC ACID AMIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | Dainippon Pharmaceutical Co., Ltd. (JP) | 1989-01-11 | — | — | EP | disclosed |