Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | STAT3 | P40763 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL756530 | 0.89 | STIM1 (0.42) | SMN1; SMN2HTTNPSR1LMNANPC1 | |
| Trifluoroacetic Acid SCHEMBL757058 | 0.78 | STIM1 (0.52) | SMN1; SMN2HTTNPSR1LMNAPTGER1 | |
| SCHEMBL7893967 | 0.77 | STIM1 (0.52) | SMN1; SMN2HTTNPSR1LMNAPTGER1 | |
| SCHEMBL756041 | 0.77 | STIM1 (0.42) | SMN1; SMN2HTTNPSR1LMNAPTGER1 | |
| SCHEMBL3051682 | 0.76 | STIM1 (0.41) | SMN1; SMN2HTTNPSR1LMNANPC1 | |
| SCHEMBL759111 | 0.70 | STIM1 (0.40) | P2RX7 | |
| SCHEMBL756524 | 0.69 | STIM1 (0.52) | SMN1; SMN2HTTNPSR1LMNAPTGER1 | |
| SCHEMBL7893849 | 0.68 | STIM1 (0.69) | SMN1; SMN2HTTNPSR1LMNAPTGER1 | |
| SCHEMBL758508 | 0.67 | STIM1 (0.54) | SMN1; SMN2HTTNPSR1LMNAPTGER1 | |
| Trifluoroacetic Acid SCHEMBL756529 | 0.67 | STIM1 (0.65) | SMN1; SMN2HTTNPSR1LMNAPTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8399436-B2 | N-pyrazolyl carboxamides as CRAC channel inhibitors | GLAXO GROUP LIMITED (GB) | 2013-03-19 | — | — | US | disclosed |
| US-20120053150-A1 | N-PYRAZOLYL CARBOXAMIDES AS CRAC CHANNEL INIHIBITORS | GLAXO GROUP LIMITED (GB) | 2012-03-01 | — | — | US | disclosed |
| US-20100273744-A1 | COMPOUNDS | GORE PAUL MARTIN | 2010-10-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120053150-A1 | N-PYRAZOLYL CARBOXAMIDES AS CRAC CHANNEL INIHIBITORS | ORAI1, TRPV1, CACNA1E | SMN1; SMN2 2239/4885HTT 2677/4885NPSR1 1293/4885 |
| US-20100273744-A1 | COMPOUNDS | LTC4S, HRH4, HRH2 | SMN1; SMN2 3063/4885HTT 2082/4885NPSR1 1288/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.