Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 7/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | THPO | P40225 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.57 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22956120 | 0.81 | GRM5 (0.50) | GRM5NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL6793023 | 0.81 | GRM5 (0.56) | GRM5NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL22955818 | 0.77 | TGFBR1 (0.56) | GRM5NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL23389782 | 0.76 | GRM5 (0.51) | GRM5NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL29796516 | 0.76 | GRM5 (0.51) | GRM5NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL6791706 | 0.76 | GRM5 (0.51) | GRM5NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL5919617 | 0.76 | GRM5 (0.66) | GRM5NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL4713737 | 0.76 | GRM5 (0.71) | GRM5NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL24494372 | 0.75 | GRM5 (0.76) | GRM5NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL4712504 | 0.75 | GRM5 (0.65) | GRM5NPC1RAB9ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002055077-A1 | USE OF IMIDAZOLYL CYCLIC ACETAL DERIVATIVES IN THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF DISEASES MEDIATED BY THE ALK5 RECEPTORS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-07-18 | — | — | WO | disclosed |