Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEP1B | Q16820 | 5/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.40 |
| ▸ | CES1 | P23141 | 2/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | CTSD | P07339 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | MEP1A | Q16819 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14638355 | 1.00 | MEP1B (0.43) | MEP1BPTPN1HDAC8HDAC3HDAC1 | |
| SCHEMBL21425218 | 1.00 | MEP1B (0.43) | MEP1BPTPN1HDAC8HDAC3HDAC1 | |
| SCHEMBL11564900 | 0.81 | CES1 (0.50) | HDAC8CES1CES2AKR1B1MEN1 | |
| SCHEMBL11564897 | 0.81 | CES1 (0.50) | HDAC8CES1CES2AKR1B1MEN1 | |
| SCHEMBL4210848 | 0.76 | MEP1B (0.47) | MEP1BPTPN1HDAC8HDAC3HDAC1 | |
| SCHEMBL3917561 | 0.76 | CES1 (0.52) | HDAC8CES1CES2AKR1B1MEN1 | |
| SCHEMBL3917563 | 0.76 | CES1 (0.52) | HDAC8CES1CES2AKR1B1MEN1 | |
| SCHEMBL6906964 | 0.74 | NPC1 (0.47) | MEP1BPTPN1HDAC8HDAC3HDAC1 | |
| SCHEMBL20954638 | 0.73 | CES1 (0.48) | HDAC8CES1CES2AKR1B1MEN1 | |
| SCHEMBL186172 | 0.72 | MEP1B (0.50) | MEP1BHDAC8HDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0984921-B1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED KETO-ENAMINES | ABBOTT LAB (US) | 2002-09-18 | — | — | EP | disclosed |
| EP-0984921-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED KETO-ENAMINES | Abbott Laboratories (US) | 2000-03-15 | — | — | EP | disclosed |
| US-5932766-A | Process for the preparation of substituted keto-enamines | ABBOTT LABORATORIES (US) | 1999-08-03 | — | — | US | disclosed |
| WO-1998054122-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED KETO-ENAMINES | ABBOTT LABORATORIES (US) | 1998-12-03 | — | — | WO | disclosed |