Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPRT1 | P00492 | 6/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7980833 | 0.82 | HPRT1 (0.45) | HPRT1ALDH1A1TP53KDM4EPOLB | |
| SCHEMBL7982326 | 0.81 | HPRT1 (0.51) | HPRT1ALDH1A1KDM4EMAPT | |
| SCHEMBL7575108 | 0.81 | HPRT1 (0.53) | HPRT1 | |
| SCHEMBL7570074 | 0.81 | HPRT1 (0.53) | HPRT1ALDH1A1HPGDKDM4ELMNA | |
| SCHEMBL7567089 | 0.80 | HPRT1 (0.54) | HPRT1HSD17B10 | |
| SCHEMBL7568116 | 0.79 | HPRT1 (0.46) | HPRT1CYP2C9CYP2C19 | |
| SCHEMBL7576799 | 0.79 | HPRT1 (0.51) | HPRT1LMNA | |
| SCHEMBL7570897 | 0.79 | CA1 (0.50) | HPRT1HSD17B10ALDH1A1POLB | |
| SCHEMBL7570987 | 0.78 | MEN1 (0.51) | ALDH1A1MAPTTSHRCYP2C19LMNA | |
| SCHEMBL7570913 | 0.78 | HPRT1 (0.50) | HPRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1237890-A1 | SYNTHESIS AND METHODS OF USE OF 9-SUBSTITUTED GUANINE DERIVATIVES | Neotherapeutics, Inc. (US) | 2002-09-11 | — | — | EP | claimed |
| WO-2001029039-A1 | SYNTHESIS AND METHODS OF USE OF 9-SUBSTITUTED GUANINE DERIVATIVES | NEOTHERAPEUTICS, INC. (US) | 2001-04-26 | — | — | WO | claimed |
| EP-1237910-A2 | TRP-PROTEIN-RELATED MTR1 PROTEIN AND DNA SEQUENCE CODING THEREFOR | Johannes Gutenberg-Universität Mainz (DE) | 2002-09-11 | — | — | EP | disclosed |
| WO-2001032693-A2 | TRP-PROTEIN-RELATED MTR1 PROTEIN AND DNA SEQUENCE CODING THEREFOR | JOHANNES-GUTENBERG- UNIVERSITÄT (DE) | 2001-05-10 | — | — | WO | disclosed |