Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 7/20 | 0.60 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | IDH1 | O75874 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7505588 | 0.95 | LCK (0.62) | LCKGRIN2BSMN1; SMN2NPC1RAB9A | |
| SCHEMBL7506273 | 0.90 | LCK (0.67) | LCKMKNK2MKNK1 | |
| SCHEMBL7990480 | 0.84 | LCK (0.60) | LCKGRIN2BSMN1; SMN2NPC1RAB9A | |
| SCHEMBL7502002 | 0.83 | LCK (0.66) | LCKIDH1MKNK2MKNK1 | |
| SCHEMBL7505777 | 0.80 | LCK (0.82) | LCKGRIN2BCYP2D6CYP2C9 | |
| SCHEMBL7547581 | 0.80 | LCK (0.53) | LCKGPR119 | |
| SCHEMBL7570454 | 0.78 | LCK (0.62) | LCKMKNK2MKNK1 | |
| SCHEMBL7508722 | 0.77 | LCK (0.91) | LCKGRIN2BCYP2D6CYP2C9 | |
| SCHEMBL7547951 | 0.76 | LCK (0.57) | LCK | |
| SCHEMBL7986459 | 0.76 | LCK (0.52) | LCKMKNK2MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1206260-A4 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2002-10-30 | — | — | EP | disclosed |
| EP-1206260-A1 | SRC KINASE INHIBITOR COMPOUNDS | Merck & Co., Inc. (US) | 2002-05-22 | — | — | EP | disclosed |
| WO-2001000207-A1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO., INC. (US) | 2001-01-04 | — | — | WO | disclosed |