Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 15/20 | 0.66 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | JAK1 | P23458 | 2/20 | 0.40 |
| ▸ | TYK2 | P29597 | 2/20 | 0.40 |
| ▸ | JAK3 | P52333 | 2/20 | 0.40 |
| ▸ | IDH1 | O75874 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7506273 | 0.91 | LCK (0.67) | LCKMKNK2MKNK1JAK2JAK1 | |
| SCHEMBL7505588 | 0.86 | LCK (0.62) | LCKMKNK2MKNK1IDH1 | |
| SCHEMBL7571215 | 0.83 | LCK (0.60) | LCKMKNK2MKNK1IDH1 | |
| SCHEMBL7505733 | 0.82 | LCK (0.54) | LCKMKNK2MKNK1 | |
| SCHEMBL7507614 | 0.80 | LCK (0.56) | LCKMKNK2MKNK1 | |
| SCHEMBL7984542 | 0.80 | LCK (1.00) | LCKIDH1 | |
| SCHEMBL7579034 | 0.80 | LCK (0.57) | LCKMKNK2MKNK1 | |
| SCHEMBL7506412 | 0.80 | MKNK1 (0.50) | LCKMKNK2MKNK1 | |
| SCHEMBL7505976 | 0.79 | LCK (0.43) | LCKMKNK2MKNK1 | |
| SCHEMBL7504210 | 0.79 | LCK (1.00) | LCKMKNK2MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1206260-A4 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2002-10-30 | — | — | EP | disclosed |
| EP-1206260-A1 | SRC KINASE INHIBITOR COMPOUNDS | Merck & Co., Inc. (US) | 2002-05-22 | — | — | EP | disclosed |
| WO-2001000207-A1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO., INC. (US) | 2001-01-04 | — | — | WO | disclosed |