SCHEMBL757123

SCHEMBL757123

CC1(C)COC(c2cccc(-c3cccc4ccccc34)n2)=N1

nearest known ligand 0.72

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.72
NPC1 O15118 2/20 0.40
MAPT P10636 2/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
RAB9A P51151 1/20 0.40
ALDH1A1 P00352 3/20 0.38
HPGD P15428 3/20 0.38
MAPK1 P28482 2/20 0.36
PTPN11 Q06124 2/20 0.36
MAPK3 P27361 1/20 0.36
ENPP3 O14638 1/20 0.36
ENPP1 P22413 1/20 0.36
TP53 P04637 1/20 0.35
HSD17B10 Q99714 1/20 0.35
ALOX15 P16050 2/20 0.35
HTT P42858 1/20 0.35
ATM Q13315 1/20 0.35
DHFR P00374 1/20 0.35
HTR2C P28335 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20409671 0.90 KDM4E (0.65) KDM4ENPC1MAPTSMN1; SMN2RAB9A
SCHEMBL8855999 0.85 KDM4E (1.00) KDM4EMAPTALDH1A1HPGDMAPK1
SCHEMBL20409963 0.84 KDM4E (0.79) KDM4EMAPTALDH1A1HPGDHTT
Hydrochloric Acid SCHEMBL7171692 0.82 KDM4E (0.93) KDM4EMAPTALDH1A1HPGDMAPK1
Hydrochloric Acid SCHEMBL7171435 0.82 KDM4E (0.93) KDM4EMAPTALDH1A1HPGDMAPK1
Hydrochloric Acid SCHEMBL7174211 0.82 KDM4E (0.93) KDM4EMAPTALDH1A1HPGDMAPK1
Hydrochloric Acid SCHEMBL7181592 0.82 KDM4E (0.93) KDM4EMAPTALDH1A1HPGDMAPK1
Hydrochloric Acid SCHEMBL7176715 0.82 KDM4E (0.93) KDM4EMAPTALDH1A1HPGDMAPK1
Hydrochloric Acid SCHEMBL7173148 0.82 KDM4E (0.93) KDM4EMAPTALDH1A1HPGDMAPK1
Hydrochloric Acid SCHEMBL7175648 0.82 KDM4E (0.93) KDM4EMAPTALDH1A1HPGDMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8138348-B2 Using coordination polymerization catalyst EXXONMOBIL CHEMICAL PATENTS INC. (US) 2012-03-20 US disclosed
US-8138348-B2 Using coordination polymerization catalyst EXXONMOBIL CHEMICAL PATENTS INC. (US) 2012-03-20 US disclosed
US-20080182989-A1 Methods For Oligomerizing Olefins With Chromium Pyridine Mono-Oxazoline Catalysts EXXONMOBIL CHEMICAL PATENTS INC. 2008-07-31 US disclosed
US-20080182989-A1 Methods For Oligomerizing Olefins With Chromium Pyridine Mono-Oxazoline Catalysts EXXONMOBIL CHEMICAL PATENTS INC. 2008-07-31 US disclosed
WO-2008085655-A1 METHODS FOR OLIGOMERIZING OLEFINS WITH CHROMIUM PYRIDINE MONO-OXAZOLINE CATALYSTS EXXONMOBIL CHEMICAL PATENTS INC. (US) 2008-07-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080182989-A1 Methods For Oligomerizing Olefins With Chromium Pyridine Mono-Oxazoline Catalysts OXER1, OXGR1, OXA1L KDM4E 2632/4885NPC1 3998/4885MAPT 2924/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.