Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 16/20 | 0.45 |
| ▸ | CTSD | P07339 | 3/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.34 |
| ▸ | PRF1 | P14222 | 1/20 | 0.34 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12174249 | 0.86 | BACE1 (0.43) | BACE1CTSDMCHR1PRF1TNF | |
| SCHEMBL8205555 | 0.86 | BACE1 (0.43) | BACE1CTSDMCHR1PRF1TNF | |
| SCHEMBL7563658 | 0.75 | BACE1 (0.43) | BACE1CTSDMCHR1 | |
| SCHEMBL12174116 | 0.75 | BACE1 (0.43) | BACE1CTSDMCHR1 | |
| SCHEMBL2970637 | 0.75 | BACE1 (0.43) | BACE1CTSDMCHR1 | |
| SCHEMBL7570163 | 0.73 | ADAM17 (0.37) | BACE1MCHR1TNF | |
| SCHEMBL12174298 | 0.73 | ADAM17 (0.37) | BACE1MCHR1TNF | |
| SCHEMBL13558713 | 0.73 | ADAM17 (0.37) | BACE1MCHR1TNF | |
| SCHEMBL7553706 | 0.73 | ADAM17 (0.37) | BACE1MCHR1TNF | |
| SCHEMBL12174420 | 0.73 | ADAM17 (0.37) | BACE1MCHR1TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8183252-B2 | Heterocyclic aspartyl protease inhibitors | SCHERING CORPORATION (US) | 2012-05-22 | — | — | US | disclosed |
| US-20100292203-A1 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS | SCHERING CORPORATION | 2010-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292203-A1 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS | CHRM1, CHRM2, PRSS1 | BACE1 8/4885CTSD 13/4885MCHR1 830/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.