Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 7/20 | 1.00 |
| ▸ | GRIA2 | P42262 | 7/20 | 1.00 |
| ▸ | GRIA3 | P42263 | 7/20 | 1.00 |
| ▸ | GRIA4 | P48058 | 7/20 | 1.00 |
| ▸ | GRIN1 | Q05586 | 7/20 | 0.48 |
| ▸ | GRIN2D | O15399 | 6/20 | 0.48 |
| ▸ | GRIN3B | O60391 | 6/20 | 0.48 |
| ▸ | GRIN2A | Q12879 | 6/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.48 |
| ▸ | GRIN2C | Q14957 | 6/20 | 0.48 |
| ▸ | GRIN3A | Q8TCU5 | 6/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL7591992 | 0.99 | GRIA1 (0.98) | GRIA1GRIA2GRIA3GRIA4GRIN1 | |
| SCHEMBL8636235 | 0.87 | GRIA1 (0.83) | GRIA1GRIA2GRIA3GRIA4GRIN1 | |
| SCHEMBL7569079 | 0.87 | GRIA1 (1.00) | GRIA1GRIA2GRIA3GRIA4GRIN1 | |
| SCHEMBL7564476 | 0.81 | GRIA1 (1.00) | GRIA1GRIA2GRIA3GRIA4GRIN1 | |
| Ammonia Solution, Strong SCHEMBL7591982 | 0.76 | GRIA1 (0.61) | GRIA1GRIA2GRIA3GRIA4GRIN1 | |
| SCHEMBL8563861 | 0.76 | GRIA1 (0.61) | GRIA1GRIA2GRIA3GRIA4 | |
| Bromide SCHEMBL8090257 | 0.75 | GRIA1 (0.60) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL7567780 | 0.75 | GRIA1 (0.60) | GRIA1GRIA2GRIA3GRIA4GRIN1 | |
| SCHEMBL7567792 | 0.75 | GRIA1 (0.60) | GRIA1GRIA2GRIA3GRIA4GRIN1 | |
| SCHEMBL7573065 | 0.75 | GRIA1 (0.65) | GRIA1GRIA2GRIA3GRIA4GRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832074-B1 | AMINO ACID DERIVATIVES OF SUBSTITUTED QUINOXALINE 2,3-DIONE DERIVATIVES AS GLUTAMATE RECEPTOR ANTAGONISTS | WARNER LAMBERT CO (US) | 2002-09-04 | — | — | EP | claimed |
| EP-0832074-A1 | AMINO ACID DERIVATIVES OF SUBSTITUTED QUINOXALINE 2,3-DIONE DERIVATIVES AS GLUTAMATE RECEPTOR ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1998-04-01 | — | — | EP | claimed |
| US-5614508-A | ANTIISCHEMIC AGENTS, ALZHEIMERS, STROKE OR NERVOUS SYSTEM DISORDERS | WARNER-LAMBERT COMPANY (US) | 1997-03-25 | — | — | US | claimed |
| WO-1996040649-A1 | AMINO ACID DERIVATIVES OF SUBSTITUTED QUINOXALINE 2,3-DIONE DERIVATIVES AS GLUTAMATE RECEPTOR ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1996-12-19 | — | — | WO | claimed |