Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 8/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.41 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL734521 | 0.83 | PIK3CG (0.55) | PIK3CGPIK3CDALDH1A1HSD17B10RXFP1 | |
| SCHEMBL17805206 | 0.79 | PIK3CG (0.47) | PIK3CGPIK3CDALDH1A1HSD17B10RXFP1 | |
| SCHEMBL18548675 | 0.76 | PIK3CG (0.51) | PIK3CGPIK3CDALDH1A1HSD17B10RXFP1 | |
| SCHEMBL732945 | 0.75 | PIK3CG (0.69) | PIK3CGPIK3CDALDH1A1HSD17B10RXFP1 | |
| SCHEMBL10296666 | 0.73 | LMNA (0.56) | PIK3CGPIK3CDALDH1A1HSD17B10RXFP1 | |
| SCHEMBL734970 | 0.72 | PIK3CG (0.52) | PIK3CGPIK3CDALDH1A1HSD17B10RXFP1 | |
| SCHEMBL732815 | 0.71 | PIK3CG (0.51) | PIK3CGPIK3CDALDH1A1HSD17B10RXFP1 | |
| SCHEMBL18526831 | 0.69 | PIK3CD (0.46) | PIK3CGPIK3CDHSD17B10PIK3R1PIK3CA | |
| SCHEMBL734922 | 0.68 | PIK3CD (0.60) | PIK3CGPIK3CDHSD17B10PIK3R1PIK3CA | |
| SCHEMBL735026 | 0.68 | PIK3CG (0.77) | PIK3CGPIK3CDALDH1A1HSD17B10RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138195-B2 | Inhibitors of human phosphatidylinositol 3-kinase delta | ICOS CORPORATION (US) | 2012-03-20 | — | — | US | disclosed |
| US-8138195-B2 | Inhibitors of human phosphatidylinositol 3-kinase delta | ICOS CORPORATION (US) | 2012-03-20 | — | — | US | disclosed |