Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.63 |
| ▸ | MAPK13 | O15264 | 12/20 | 0.63 |
| ▸ | MAPK12 | P53778 | 12/20 | 0.63 |
| ▸ | MAPK11 | Q15759 | 12/20 | 0.63 |
| ▸ | GRM4 | Q14833 | 4/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7080441 | 0.89 | MAPK14 (0.68) | MAPK14MAPK13MAPK12MAPK11GRM4 | |
| SCHEMBL7566947 | 0.87 | MAPK14 (0.51) | MAPK14MAPK13MAPK12MAPK11GRM4 | |
| SCHEMBL7080273 | 0.84 | MAPK14 (0.68) | MAPK14MAPK13MAPK12MAPK11GRM4 | |
| SCHEMBL7571963 | 0.82 | MAPK14 (0.64) | MAPK14MAPK13MAPK12MAPK11GRM4 | |
| SCHEMBL7082605 | 0.81 | MAPK14 (0.70) | MAPK14MAPK13MAPK12MAPK11GRM4 | |
| SCHEMBL7082606 | 0.78 | MAPK14 (0.55) | MAPK14MAPK13MAPK12MAPK11GRM4 | |
| SCHEMBL1904637 | 0.78 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11TP53 | |
| SCHEMBL7079244 | 0.78 | MAPK14 (0.75) | MAPK14MAPK13MAPK12MAPK11TP53 | |
| SCHEMBL7079647 | 0.76 | MAPK14 (0.65) | MAPK14MAPK13MAPK12MAPK11GRM4 | |
| SCHEMBL7079512 | 0.76 | MAPK14 (0.53) | MAPK14MAPK13MAPK12MAPK11GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002083622-A2 | NOVEL AMINOPHENYL KETONE DERIVATIVES | LEO PHARMA A/S (DK) | 2002-10-24 | — | — | WO | claimed |
| WO-2002083622-A2 | NOVEL AMINOPHENYL KETONE DERIVATIVES | LEO PHARMA A/S (DK) | 2002-10-24 | — | — | WO | disclosed |