Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR2 | P21802 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 9/20 | 0.44 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4380606 | 0.99 | FGFR2 (0.50) | FGFR2KDM4EMEN1NPC1KMT2A | |
| SCHEMBL4380603 | 0.99 | FGFR2 (0.50) | FGFR2KDM4EMEN1NPC1KMT2A | |
| SCHEMBL5458902 | 0.91 | BRD4 (0.49) | FGFR2KDM4EMEN1NPC1KMT2A | |
| SCHEMBL5217568 | 0.90 | EGFR (0.53) | FGFR2MEN1KMT2ATSHRADRB2 | |
| SCHEMBL4371030 | 0.84 | ABCB1 (0.43) | FGFR2AURKAABCB1 | |
| SCHEMBL4371022 | 0.84 | ABCB1 (0.43) | FGFR2AURKAABCB1 | |
| SCHEMBL4380551 | 0.82 | EHMT2 (0.53) | EGFR | |
| SCHEMBL2924579 | 0.81 | EHMT2 (0.60) | — | |
| SCHEMBL5498950 | 0.81 | EHMT2 (0.54) | EGFR | |
| SCHEMBL4686452 | 0.80 | EHMT2 (0.61) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002092577-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2002-11-21 | — | — | WO | disclosed |