SCHEMBL5498950

SCHEMBL5498950

COc1cc2c(=O)[nH]cnc2cc1OCCN1CCCC1

nearest known ligand 0.54

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
EHMT2 Q96KQ7 8/20 0.54
EHMT1 Q9H9B1 8/20 0.54
KDR P35968 4/20 0.50
EPHA2 P29317 2/20 0.50
EPHB4 P54760 2/20 0.50
SPIN1 Q9Y657 2/20 0.48
MCHR1 Q99705 2/20 0.48
EGFR P00533 2/20 0.48
FGFR1 P11362 1/20 0.48
FLT1 P17948 1/20 0.48
IP6K1 Q92551 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4380551 0.99 EHMT2 (0.53) EHMT2EHMT1KDREPHA2EPHB4
SCHEMBL4686452 0.94 EHMT2 (0.61) EHMT2EHMT1KDRSPIN1
SCHEMBL2924579 0.93 EHMT2 (0.60) EHMT2EHMT1KDRSPIN1
SCHEMBL7215157 0.92 EGFR (0.48) EHMT2EHMT1KDREGFRFGFR1
SCHEMBL7209967 0.90 KDR (0.52) KDREPHA2EPHB4EGFRFGFR1
SCHEMBL7211058 0.90 PDGFRB (0.47) EHMT2EHMT1KDREPHA2EPHB4
SCHEMBL4025116 0.86 EHMT2 (0.52) EHMT2EHMT1KDREPHA2EPHB4
SCHEMBL5218230 0.86 EHMT2 (0.49) EHMT2EHMT1KDREGFRFGFR1
SCHEMBL26020253 0.85 IP6K1 (0.54) EHMT2EHMT1SPIN1MCHR1IP6K1
SCHEMBL29478512 0.84 KDM1A (0.57) KDREPHB4EGFRFGFR1FLT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1005470-B1 OXINDOLYLQUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS ASTRAZENECA AB (SE) 2007-08-01 EP disclosed
EP-0912557-B1 OXINDOLE DERIVATIVES ASTRAZENECA AB (SE) 2003-07-09 EP disclosed
EP-0880508-B1 QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS ASTRAZENECA AB (SE) 2003-04-16 EP disclosed
US-6294532-B1 TREATMENT OF A NUMBER OF DISEASE STATES INCLUDING CANCER AND RHEUMATOID ARTHRITIS. ZENECA LIMITED (GB) 2001-09-25 US disclosed
US-6265411-B1 ANGIOGENESIS INHIBITOR ZENECA LIMITED (GB) 2001-07-24 US disclosed
US-6184225-B1 ENDOTHELIAL GROWTH FACTOR INHIBITORS, ANGIOGENESIS INHIBITORS ZENECA LIMITED (GB) 2001-02-06 US disclosed
EP-1005470-A1 OXINDOLYLQUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS ZENECA LIMITED (GB) 2000-06-07 EP disclosed
EP-0912557-A1 OXINDOLE DERIVATIVES ZENECA LIMITED (GB) 1999-05-06 EP disclosed
WO-1999010349-A1 OXINDOLYLQUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS ZENECA LIMITED (GB) 1999-03-04 WO disclosed
EP-0880508-A1 QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS ZENECA LIMITED (GB) 1998-12-02 EP disclosed
WO-1997042187-A1 OXINDOLE DERIVATIVES ZENECA LIMITED (GB) 1997-11-13 WO disclosed
WO-1997030035-A1 QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS ZENECA LIMITED (GB) 1997-08-21 WO disclosed