Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 13/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.59 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.59 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7569231 | 0.87 | P2RX7 (0.58) | P2RX7MEN1ALDH1A1KMT2AAVPR1A | |
| SCHEMBL4876478 | 0.87 | P2RX7 (0.68) | P2RX7MEN1ALDH1A1KMT2AAVPR1A | |
| SCHEMBL7577116 | 0.87 | P2RX7 (0.55) | P2RX7MEN1ALDH1A1KMT2AAVPR1A | |
| SCHEMBL7568709 | 0.83 | P2RX7 (1.00) | P2RX7MEN1ALDH1A1KMT2A | |
| SCHEMBL4880000 | 0.80 | P2RX7 (0.59) | P2RX7MEN1ALDH1A1KMT2AAVPR1A | |
| SCHEMBL19321961 | 0.80 | P2RX7 (0.63) | P2RX7MEN1ALDH1A1KMT2AAVPR1A | |
| SCHEMBL4877202 | 0.79 | P2RX7 (0.67) | P2RX7MEN1ALDH1A1KMT2AAVPR1A | |
| SCHEMBL19354785 | 0.78 | P2RX7 (0.72) | P2RX7MEN1ALDH1A1KMT2AHDAC11 | |
| SCHEMBL7665408 | 0.78 | P2RX7 (0.78) | P2RX7MEN1ALDH1A1KMT2AAVPR1A | |
| SCHEMBL4880025 | 0.77 | P2RX7 (0.68) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1036059-B1 | ADAMANTANE DERIVATIVES | ASTRAZENECA UK LTD (GB) | 2002-09-18 | — | — | EP | claimed |
| EP-1036059-B1 | ADAMANTANE DERIVATIVES | ASTRAZENECA UK LTD (GB) | 2002-09-18 | — | — | EP | disclosed |