Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 12/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 12/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7566171 | 0.98 | SLC6A4 (0.57) | SLC6A4SLC6A3HDAC4CYP3A4ALOX15 | |
| SCHEMBL4439597 | 0.96 | SLC6A4 (0.50) | SLC6A4SLC6A3HDAC4CYP3A4ALOX15 | |
| SCHEMBL4445342 | 0.94 | SLC6A4 (0.46) | SLC6A4SLC6A3HDAC4CYP3A4ALOX15 | |
| SCHEMBL7563624 | 0.85 | SLC6A4 (0.40) | SLC6A4SLC6A3HDAC4CYP3A4ALOX15 | |
| SCHEMBL3408732 | 0.81 | SLC6A4 (0.51) | SLC6A4SLC6A3HDAC4CYP3A4ALOX15 | |
| SCHEMBL3413223 | 0.79 | SLC6A4 (0.54) | SLC6A4SLC6A3HDAC4CYP3A4ALOX15 | |
| SCHEMBL4437272 | 0.78 | LIG1 (0.32) | SLC6A4SLC6A3OPRK1 | |
| SCHEMBL3408485 | 0.77 | SLC6A4 (0.47) | SLC6A4SLC6A3HDAC4CYP3A4ALOX15 | |
| SCHEMBL4435176 | 0.77 | MEN1 (0.36) | SLC6A4SLC6A3HDAC4TSHRSLC6A2 | |
| SCHEMBL3406111 | 0.76 | SLC6A4 (0.42) | SLC6A4SLC6A3HDAC4CYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002083863-A2 | THIAZOLE AND OTHER HETEROCYCLIC LIGANDS AND USE THEREOF | SEPRACOR, INC. (US) | 2002-10-24 | — | — | WO | disclosed |