Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | PNMT | P11086 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4445342 | 0.82 | SLC6A4 (0.46) | TSHRHDAC4OPRK1MAOAMAOB | |
| SCHEMBL4437272 | 0.80 | LIG1 (0.32) | OPRM1OPRK1OPRL1MAOAMAOB | |
| SCHEMBL19207558 | 0.78 | HDAC4 (0.39) | MEN1CYP2C9KMT2AAKR1C1HDAC4 | |
| SCHEMBL4439597 | 0.77 | SLC6A4 (0.50) | TSHRHDAC4OPRK1SLC6A2SLC6A4 | |
| SCHEMBL7572201 | 0.77 | SLC6A4 (0.54) | TSHRHDAC4OPRK1SLC6A2SLC6A4 | |
| SCHEMBL7566171 | 0.76 | SLC6A4 (0.57) | TSHRHDAC4OPRK1SLC6A2SLC6A4 | |
| SCHEMBL1952823 | 0.76 | SLC6A4 (0.50) | MEN1KMT2ATSHROPRM1OPRK1 | |
| SCHEMBL4445384 | 0.75 | HDAC4 (0.40) | MEN1KMT2ATSHRHDAC4OPRM1 | |
| SCHEMBL7563624 | 0.73 | SLC6A4 (0.40) | TSHRHDAC4OPRK1SLC6A2SLC6A4 | |
| SCHEMBL7571205 | 0.72 | ICMT (0.40) | MEN1KMT2ASLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134692-A2 | QUINOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM FOR SELECTIN INHIBITION | Wyeth a Corporation of the State of Delaware (US) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008121817-A2 | QUINOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM FOR SELECTIN INHIBITION | WYETH (US) | 2008-10-09 | — | — | WO | disclosed |