Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 17/20 | 0.38 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL756877 | 1.00 | BACE1 (0.38) | BACE1BACE2ALDH1A1 | |
| SCHEMBL764599 | 0.94 | BACE1 (0.41) | BACE1BACE2 | |
| SCHEMBL4739104 | 0.94 | BACE1 (0.41) | BACE1BACE2 | |
| Trifluoroacetic Acid SCHEMBL755052 | 0.91 | AURKA (0.42) | BACE1BACE2ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL757205 | 0.91 | AURKA (0.42) | BACE1BACE2ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL757608 | 0.88 | BACE1 (0.36) | BACE1BACE2 | |
| Trifluoroacetic Acid SCHEMBL755302 | 0.88 | BACE1 (0.36) | BACE1BACE2 | |
| SCHEMBL764637 | 0.88 | BACE1 (0.47) | BACE1BACE2 | |
| SCHEMBL4786910 | 0.87 | HSD11B1 (0.41) | BACE1BACE2ALDH1A1 | |
| SCHEMBL757501 | 0.87 | HSD11B1 (0.41) | BACE1BACE2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8211904-B2 | Spiropiperidine beta-secretase inhibitors for the treatment of alzheimer's disease | Merck, Sharp & Dohme Corp. (US) | 2012-07-03 | — | — | US | disclosed |
| EP-1910364-B1 | SPIROPIPERIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME (US) | 2012-03-21 | — | — | EP | disclosed |
| US-20070021454-A1 | Spiropiperidine beta-secretase inhibitors for the treatment of Alzheimer's disease | MERCK SHARP & DOHME LLC | 2007-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070021454-A1 | Spiropiperidine beta-secretase inhibitors for the treatment of Alzheimer's disease | BACE1, APP, PSEN1 | BACE1 1/4885BACE2 4/4885ALDH1A1 717/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.