Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 8/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 7/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 6/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.45 |
| ▸ | PI4KA | P42356 | 1/20 | 0.42 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.42 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.42 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7206725 | 0.87 | PI4KA (0.59) | ADORA2AADORA3ADORA2BADORA1PI4KA | |
| SCHEMBL7573120 | 0.83 | ADORA2A (0.65) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL13461113 | 0.81 | ADORA3 (0.50) | ADORA2AADORA3ADORA2BADORA1PI4KA | |
| SCHEMBL7932677 | 0.81 | ADORA3 (0.50) | ADORA2AADORA3ADORA2BADORA1PI4KA | |
| SCHEMBL12568226 | 0.81 | ADORA3 (0.50) | ADORA2AADORA3ADORA2BADORA1PI4KA | |
| SCHEMBL13296261 | 0.81 | ADORA3 (0.50) | ADORA2AADORA3ADORA2BADORA1PI4KA | |
| SCHEMBL13913203 | 0.81 | PI4KA (0.50) | ADORA2AADORA3ADORA2BADORA1PI4KA | |
| SCHEMBL326428 | 0.81 | PI4KA (0.50) | ADORA2AADORA3ADORA2BADORA1PI4KA | |
| SCHEMBL13433886 | 0.81 | ADORA3 (0.50) | ADORA2AADORA3ADORA2BADORA1PI4KA | |
| SCHEMBL2115858 | 0.81 | ADORA3 (0.50) | ADORA2AADORA3ADORA2BADORA1PI4KA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1056759-B1 | 2-(PURIN-9-YL) -TETRAHYDROFURAN-3, 4-DIOL DERIVATIVES | GLAXO GROUP LTD (GB) | 2002-09-04 | — | — | EP | disclosed |
| EP-1056759-A1 | 2-(PURIN-9-YL) -TETRAHYDROFURAN-3, 4-DIOL DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999041267-A1 | 2-(PURIN-9-YL) -TETRAHYDROFURAN-3, 4-DIOL DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1999-08-19 | — | — | WO | disclosed |