Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | EDNRA | P25101 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8771517 | 0.92 | ALDH1A1 (0.42) | EDNRBALDH1A1SMN1; SMN2L3MBTL1ALPL | |
| SCHEMBL7951404 | 0.86 | EDNRB (0.51) | EDNRBALDH1A1SMN1; SMN2L3MBTL1ALPL | |
| SCHEMBL7567452 | 0.84 | EDNRA (0.56) | EDNRBALDH1A1SMN1; SMN2EDNRAGAA | |
| SCHEMBL7567416 | 0.83 | EDNRB (0.70) | EDNRBALDH1A1SMN1; SMN2L3MBTL1EDNRA | |
| SCHEMBL7570801 | 0.83 | EDNRB (0.42) | EDNRBALDH1A1EDNRAMAPK1SLC6A2 | |
| SCHEMBL7575128 | 0.82 | EDNRA (0.47) | EDNRBALDH1A1EDNRA | |
| SCHEMBL7567913 | 0.79 | EDNRA (0.54) | EDNRBALDH1A1EDNRAMEN1KMT2A | |
| SCHEMBL7567566 | 0.77 | EDNRA (0.54) | EDNRBALDH1A1SMN1; SMN2L3MBTL1EDNRA | |
| SCHEMBL7573709 | 0.77 | EDNRB (0.46) | EDNRBALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL8049633 | 0.76 | EDNRB (0.59) | EDNRBALDH1A1SMN1; SMN2L3MBTL1EDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799206-A1 | ARYL- AND HETARYL-SULFONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ENDOTHELIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1997-10-08 | — | — | EP | disclosed |
| WO-1996019455-A1 | ARYL- AND HETARYL-SULFONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ENDOTHELIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1996-06-27 | — | — | WO | disclosed |