Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CASP3 | P42574 | 4/20 | 0.42 |
| ▸ | MDM4 | O15151 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6855718 | 0.96 | MDM2 (0.46) | MDM2KMT2ACASP3MDM4TP53 | |
| Succinic Acid SCHEMBL7573727 | 0.93 | MDM2 (0.44) | MDM2KMT2ACASP3MDM4TP53 | |
| SCHEMBL6856061 | 0.89 | MDM2 (0.46) | MDM2KMT2ACASP3MDM4TP53 | |
| SCHEMBL26005609 | 0.89 | CASP3 (0.46) | MDM2KMT2ACASP3MDM4TP53 | |
| SCHEMBL25631518 | 0.88 | KMT2A (0.45) | MDM2KMT2ACASP3MDM4TP53 | |
| SCHEMBL7573711 | 0.88 | MDM2 (0.44) | MDM2KMT2ACASP3MDM4TP53 | |
| SCHEMBL25280271 | 0.84 | MDM2 (0.55) | MDM2CASP3MDM4TP53 | |
| SCHEMBL31749819 | 0.84 | MDM2 (0.55) | MDM2CASP3MDM4TP53 | |
| SCHEMBL8059732 | 0.84 | MDM2 (0.55) | MDM2CASP3MDM4TP53 | |
| SCHEMBL19900833 | 0.83 | KMT2A (0.47) | KMT2ACASP3MDM4TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0751948-B1 | NOVEL PHOSPHORAMIDATE AND PHOPHOROTHIOAMIDATE OLIGOMERIC COMPOUNDS | ISIS PHARMACEUTICALS INC (US) | 2002-09-25 | — | — | EP | disclosed |
| US-6184389-B1 | FEATURE A PLURALITY OF FUNCTIONAL GROUPS ATTACHED TO BACKBONE AND PHOSPHORAMIDATE SITES | ISIS PHARMACEUTICALS, INC. | 2001-02-06 | — | — | US | disclosed |
| US-5717083-A | COMPLEXING WITH PROTEINS, NUCLEIC ACIDS, LIPIDS | ISIS PHARMACEUTICALS, INC. (US) | 1998-02-10 | — | — | US | disclosed |
| EP-0751948-A4 | NOVEL PHOSPHORAMIDATE AND PHOPHOROTHIOAMIDATE OLIGOMERIC COMPOUNDS | ISIS PHARMACEUTICALS INC (US) | 1997-03-19 | — | — | EP | disclosed |
| EP-0751948-A1 | NOVEL PHOSPHORAMIDATE AND PHOPHOROTHIOAMIDATE OLIGOMERIC COMPOUNDS | ISIS PHARMACEUTICALS, INC. (US) | 1997-01-08 | — | — | EP | disclosed |
| WO-1995023160-A1 | NOVEL PHOSPHORAMIDATE AND PHOPHOROTHIOAMIDATE OLIGOMERIC COMPOUNDS | ISIS PHARMACEUTICALS, INC. (US) | 1995-08-31 | — | — | WO | disclosed |