Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 2/20 | 0.48 |
| ▸ | OGG1 | O15527 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31326059 | 1.00 | PDE5A (0.48) | PDE5AOGG1CNR1CNR2HCRTR1 | |
| SCHEMBL27580633 | 0.95 | PDE5A (0.42) | PDE5AOGG1CNR1CNR2HCRTR1 | |
| SCHEMBL30200310 | 0.91 | HTR3A (0.41) | PDE5AOGG1HCRTR1HCRTR2LCK | |
| SCHEMBL15819435 | 0.91 | HTR3A (0.41) | PDE5AOGG1HCRTR1HCRTR2LCK | |
| SCHEMBL22025139 | 0.83 | PDE5A (0.35) | PDE5AOGG1CNR1CNR2HCRTR1 | |
| SCHEMBL20993437 | 0.83 | CDK7 (0.40) | OGG1HCRTR1HCRTR2HTR3AHRH4 | |
| SCHEMBL20993222 | 0.83 | CDK7 (0.40) | OGG1HCRTR1HCRTR2HTR3AHRH4 | |
| SCHEMBL20993375 | 0.83 | CDK7 (0.40) | OGG1HCRTR1HCRTR2HTR3AHRH4 | |
| SCHEMBL3207882 | 0.83 | CDK7 (0.40) | PDE5AOGG1HCRTR1HCRTR2HTR3A | |
| SCHEMBL4963862 | 0.83 | MEN1 (0.46) | TDP1HTR3AHRH4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119504611-A | Method for synthesizing quinazoline derivative by manganese-based catalyst | 西安近代化学研究所 | 2025-02-25 | — | — | CN | disclosed |
| US-20220119400-A1 | QUINAZOLINE AND INDOLE COMPOUNDS TO TREAT MEDICAL DISORDERS | ACHILLION PHARMACEUTICALS INC (US) | 2022-04-21 | — | — | US | disclosed |
| CN-108264489-B | Method for synthesizing quinazoline in water | 南京理工大学 | 2021-06-08 | — | — | CN | disclosed |
| CN-108264489-A | A kind of method for synthesizing quinazoline in water | 南京理工大学 | 2018-07-10 | — | — | CN | disclosed |
| US-6380205-B1 | QUINAZOLINE THROUGH A C1-C4ALKYL, C1- C4ALKENYL, C1-C4ALKYNYL, C1-C4ALKOXY, AMINO, AMINOC1-C4ALKYL, HYDROXYC1-C4ALKYL, CARBONYL, CYCLOC3-C6ALKYL OR AMINOCARBONYL CHAIN, USEFUL FOR TREATMENT OF THE PAIN | MERCK & CO., INC. | 2002-04-30 | — | — | US | disclosed |
| US-20020032207-A1 | 2-Cyclohexyl quinazoline NMDA/NR2B antagonists | MERCK & CO., INC. | 2002-03-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220119400-A1 | QUINAZOLINE AND INDOLE COMPOUNDS TO TREAT MEDICAL DISORDERS | CFB, TFPI, MAOB | PDE5A 2351/4885OGG1 4383/4885CNR1 202/4885 |
| US-20020032207-A1 | 2-Cyclohexyl quinazoline NMDA/NR2B antagonists | GRIN2C, GRIN1, GRIN3A | PDE5A 4188/4885OGG1 3851/4885CNR1 36/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.