Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 1/20 | 0.50 |
| ▸ | MKNK2 | Q9HBH9 | 11/20 | 0.47 |
| ▸ | LCK | P06239 | 5/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 12/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7024505 | 0.74 | ROCK1 (0.51) | ROCK1MKNK2LCKMKNK1POLB | |
| SCHEMBL21554382 | 0.70 | ROCK1 (0.68) | ROCK1MKNK2LCKMKNK1POLB | |
| SCHEMBL6039615 | 0.68 | ROCK1 (0.68) | ROCK1MKNK2LCKMKNK1POLB | |
| SCHEMBL12821560 | 0.68 | ROCK1 (1.00) | ROCK1MKNK2LCKMKNK1POLB | |
| SCHEMBL7024738 | 0.67 | ROCK1 (0.62) | ROCK1MKNK2LCKMKNK1POLB | |
| SCHEMBL8177049 | 0.67 | APAF1 (0.49) | POLB | |
| SCHEMBL7025485 | 0.67 | LCK (0.75) | MKNK2LCKMKNK1 | |
| SCHEMBL7576903 | 0.67 | LCK (0.75) | MKNK2LCKMKNK1 | |
| SCHEMBL2147667 | 0.66 | POLB (0.70) | ROCK1MKNK2LCKMKNK1POLB | |
| SCHEMBL31722849 | 0.66 | POLB (0.70) | ROCK1MKNK2LCKMKNK1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1206265-A4 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2002-08-07 | — | — | EP | disclosed |
| EP-1206265-A1 | SRC KINASE INHIBITOR COMPOUNDS | Merck & Co., Inc. (US) | 2002-05-22 | — | — | EP | disclosed |
| WO-2001000213-A1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO., INC. (US) | 2001-01-04 | — | — | WO | disclosed |