Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPRT1 | P00492 | 6/20 | 0.46 |
| ▸ | NOS1 | P29475 | 3/20 | 0.36 |
| ▸ | DUT | P33316 | 1/20 | 0.35 |
| ▸ | PNP | P00491 | 2/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.31 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | TYMS | P04818 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7570451 | 0.81 | HPRT1 (0.53) | HPRT1NOS1 | |
| SCHEMBL7982852 | 0.80 | HPRT1 (0.44) | HPRT1NOS1 | |
| SCHEMBL7570074 | 0.79 | HPRT1 (0.53) | HPRT1PNP | |
| SCHEMBL5253448 | 0.79 | HPRT1 (0.45) | HPRT1TAAR1MAPK1 | |
| SCHEMBL7567089 | 0.78 | HPRT1 (0.54) | HPRT1NOS1MAPK1 | |
| SCHEMBL7575961 | 0.77 | AKR1B1 (0.47) | HPRT1TYMS | |
| SCHEMBL7576799 | 0.76 | HPRT1 (0.51) | HPRT1NOS1PNPTYMS | |
| SCHEMBL7982326 | 0.76 | HPRT1 (0.51) | HPRT1NOS1 | |
| SCHEMBL5258342 | 0.74 | HPRT1 (0.48) | HPRT1TYMS | |
| SCHEMBL7567133 | 0.74 | HPRT1 (0.57) | HPRT1PNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1237890-A1 | SYNTHESIS AND METHODS OF USE OF 9-SUBSTITUTED GUANINE DERIVATIVES | Neotherapeutics, Inc. (US) | 2002-09-11 | — | — | EP | disclosed |
| WO-2001029039-A1 | SYNTHESIS AND METHODS OF USE OF 9-SUBSTITUTED GUANINE DERIVATIVES | NEOTHERAPEUTICS, INC. (US) | 2001-04-26 | — | — | WO | disclosed |