Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CXCR4 | P61073 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | CCR2 | P41597 | 1/20 | 0.40 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | BAX | Q07812 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1361158 | 0.92 | SMN1; SMN2 (0.53) | SMN1; SMN2MEN1KMT2AMAPTATM | |
| SCHEMBL20307045 | 0.85 | MEN1 (0.68) | SMN1; SMN2MEN1KMT2ACXCR4MAPT | |
| SCHEMBL9493787 | 0.83 | MAPT (0.67) | SMN1; SMN2MEN1KMT2ACXCR4MAPT | |
| SCHEMBL10476 | 0.82 | MEN1 (0.68) | SMN1; SMN2MEN1KMT2AMAPTATM | |
| SCHEMBL4382056 | 0.82 | MEN1 (0.68) | SMN1; SMN2MEN1KMT2AMAPTATM | |
| SCHEMBL7571912 | 0.82 | — | — | |
| SCHEMBL4381893 | 0.82 | MEN1 (0.68) | SMN1; SMN2MEN1KMT2AMAPTATM | |
| SCHEMBL7572149 | 0.80 | MEN1 (0.73) | MEN1KMT2AMAPTATMHSD17B10 | |
| SCHEMBL5218126 | 0.80 | MEN1 (0.73) | MEN1KMT2AMAPTATMHSD17B10 | |
| SCHEMBL4376156 | 0.80 | MEN1 (0.73) | MEN1KMT2AMAPTATMHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002092578-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2002-11-21 | — | — | WO | claimed |
| WO-2002092578-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2002-11-21 | — | — | WO | disclosed |
| WO-2002092577-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2002-11-21 | — | — | WO | disclosed |