⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11810865 | 0.76 | ABCG2 (0.34) | — | |
| SCHEMBL5342826 | 0.76 | P2RY6 (0.33) | — | |
| SCHEMBL6302024 | 0.70 | KDM1A (0.36) | — | |
| SCHEMBL8909200 | 0.70 | — | — | |
| SCHEMBL11458282 | 0.69 | PARP1 (0.36) | — | |
| SCHEMBL342296 | 0.68 | ANPEP (0.38) | — | |
| SCHEMBL3889560 | 0.67 | — | — | |
| SCHEMBL11161414 | 0.65 | — | — | |
| SCHEMBL6559581 | 0.65 | — | — | |
| SCHEMBL4891883 | 0.63 | OXTR (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3160948-B1 | BENZOXAZINONE AMIDES AS MINERALOCORTICOID RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2018-10-24 | — | — | EP | disclosed |
| US-10017502-B2 | Benzoxazinone amides as mineralocorticoid receptor modulators | ASTRAZENECA AB (SE) | 2018-07-10 | — | — | US | disclosed |
| US-20170217945-A1 | BENZOXAZINONE AMIDES AS MINERALOCORTICOID RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2017-08-03 | — | — | US | disclosed |
| EP-3160948-A1 | BENZOXAZINONE AMIDES AS MINERALOCORTICOID RECEPTOR MODULATORS | Astrazeneca AB (SE) | 2017-05-03 | — | — | EP | disclosed |
| US-9394291-B2 | Benzoxazinone amides as mineralocorticoid receptor modulators | ASTRAZENECA AB (SE) | 2016-07-19 | — | — | US | disclosed |
| WO-2016001631-A1 | BENZOXAZINONE AMIDES AS MINERALOCORTICOID RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2016-01-07 | — | — | WO | disclosed |
| US-20150376170-A1 | BENZOXAZINONE AMIDES AS MINERALOCORTICOID RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2015-12-31 | — | — | US | disclosed |
| US-8410166-B2 | Fused bicyclic compound | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2013-04-02 | — | — | US | disclosed |
| US-20130029979-A1 | FUSED BICYCLIC COMPOUND | TAKAHASHI YOICHI (JP) | 2013-01-31 | — | — | US | disclosed |
| EP-2537845-A1 | 6H-dibenzo[B,E]oxepine derived nonsteroidal mineralocorticoid receptor antagonists | Eli Lilly and Company (US) | 2012-12-26 | — | — | EP | disclosed |
| US-8258131-B2 | Fused bicyclic compound | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2012-09-04 | — | — | US | disclosed |
| US-8188073-B2 | Benzoxazines and related nitrogen-containing heterobicyclic compounds useful as mineralocorticoid receptor modulating agents | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2012-05-29 | — | — | US | disclosed |
| EP-1984345-B9 | BENZOXAZINES AND RELATED NITROGEN-CONTAINING HETEROBICYCLIC COMPOUNDS USEFUL AS MINERALOCORTICOID RECEPTOR MODULATING AGENTS | MITSUBISHI TANABE PHARMA CORP (JP) | 2012-03-21 | — | — | EP | disclosed |
| US-20110251185-A1 | BENZOXAZINES AND RELATED NITROGEN-CONTAINING HETEROBICYCLIC COMPOUNDS USEFUL AS MINERALOCORTICOID RECEPTOR MODULATING AGENTS | IIJIMA TORU | 2011-10-13 | — | — | US | disclosed |
| EP-1984345-B1 | BENZOXAZINES AND RELATED NITROGEN-CONTAINING HETEROBICYCLIC COMPOUNDS USEFUL AS MINERALOCORTICOID RECEPTOR MODULATING AGENTS | MITSUBISHI TANABE PHARMA CORP (JP) | 2011-08-31 | — | — | EP | disclosed |
| US-7998956-B2 | Benzoxazines and related nitrogen-containing heterobicyclic compounds useful as mineralocorticoid receptor modulating agents | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2011-08-16 | — | — | US | disclosed |
| US-20100204218-A1 | FUSED BICYCLIC COMPOUND | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2010-08-12 | — | — | US | disclosed |
| US-20090023716-A1 | Benzoxazines and Related Nitrogen-Containing Heterobicyclic Compounds Useful as Mineralocorticoid Receptor Modulating Agents | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2009-01-22 | — | — | US | disclosed |
| EP-1984345-A1 | BENZOXAZINES AND RELATED NITROGEN-CONTAINING HETEROBICYCLIC COMPOUNDS USEFUL AS MINERALOCORTICOID RECEPTOR MODULATING AGENTS | Mitsubishi Tanabe Pharma Corporation (JP) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007089034-A1 | BENZOXAZINES AND RELATED NITROGEN-CONTAINING HETEROBICYCLIC COMPOUNDS USEFUL AS MINERALOCORTICOID RECEPTOR MODULATING AGENTS | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2007-08-09 | — | — | WO | disclosed |