Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.57 |
| ▸ | PLIN1 | O60240 | 2/20 | 0.57 |
| ▸ | RECQL | P46063 | 2/20 | 0.57 |
| ▸ | PLIN5 | Q00G26 | 2/20 | 0.57 |
| ▸ | ABHD5 | Q8WTS1 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | F3 | P13726 | 2/20 | 0.57 |
| ▸ | TNKS | O95271 | 1/20 | 0.57 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.57 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.57 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.57 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.57 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28435739 | 0.98 | MAPT (0.59) | MAPTLMNAHDAC3HDAC4HDAC1 | |
| SCHEMBL11033432 | 0.96 | MAPT (0.57) | MAPTLMNAHDAC3HDAC4HDAC1 | |
| SCHEMBL9333787 | 0.96 | MAPT (0.57) | MAPTLMNAHDAC3HDAC4HDAC1 | |
| SCHEMBL10717498 | 0.96 | MAPT (0.57) | MAPTLMNAHDAC3HDAC4HDAC1 | |
| SCHEMBL9416654 | 0.94 | MAPT (0.59) | MAPTLMNAHDAC3HDAC4HDAC1 | |
| SCHEMBL11126196 | 0.90 | MAPT (0.55) | MAPTLMNAHDAC3HDAC4HDAC1 | |
| SCHEMBL30603824 | 0.89 | GLA (0.56) | MAPTLMNAHDAC3HDAC4HDAC1 | |
| SCHEMBL7882393 | 0.88 | CYP1B1 (0.53) | MAPTLMNAHDAC3HDAC4HDAC1 | |
| SCHEMBL29761302 | 0.87 | MAPT (0.52) | MAPTLMNAHDAC3HDAC4HDAC1 | |
| SCHEMBL18203200 | 0.85 | CYP1B1 (0.55) | MAPTLMNAHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1254884-A2 | Preparation of vinyl ethers from alcohols and alkenes | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2002-11-06 | — | — | EP | claimed |
| EP-1245553-A2 | Palladium-catalysed synthesis of aryl ethers | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2002-10-02 | — | — | EP | claimed |
| US-20010008942-A1 | Synthesis of aryl ethers | BUCHWALD STEPHEN L (US) | 2001-07-19 | — | — | US | claimed |
| EP-1027316-A1 | SYNTHESIS OF ARYL ETHERS, METHODS AND REAGENTS RELATED THERETO | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2000-08-16 | — | — | EP | claimed |
| US-5847166-A | Synthesis of aryl ethers | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1998-12-08 | — | — | US | claimed |
| WO-1998015515-A1 | SYNTHESIS OF ARYL ETHERS, METHODS AND REAGENTS RELATED THERETO | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1998-04-16 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010008942-A1 | Synthesis of aryl ethers | AHR, PAH, PDK1 | MAPT 3843/4885LMNA 2726/4885HDAC3 1343/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.