⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8720601 | 0.83 | CA1 (0.33) | — | |
| SCHEMBL11730088 | 0.82 | — | — | |
| SCHEMBL10873887 | 0.80 | CA1 (0.52) | — | |
| SCHEMBL1607820 | 0.78 | CA1 (0.42) | — | |
| SCHEMBL63094 | 0.73 | — | — | |
| SCHEMBL11883897 | 0.73 | — | — | |
| SCHEMBL10629834 | 0.73 | — | — | |
| SCHEMBL3270913 | 0.73 | — | — | |
| SCHEMBL1524940 | 0.73 | — | — | |
| SCHEMBL11155659 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260124190-A1 | METHOD FOR TREATING A DISEASE OR CONDITION USING A PYRAZOLE COMPOUND OR FORMULATION THEREOF | RIGEL PHARMACEUTICALS, INC. (US) | 2026-05-07 | — | — | US | disclosed |
| US-12441723-B2 | Pyrazole compounds, formulations thereof, and a method for using the compounds and/or formulations | RIGEL PHARMACEUTICALS, INC. (US) | 2025-10-14 | — | — | US | disclosed |
| US-12357623-B2 | Method for treating a disease or condition using a pyrazole compound or formulation thereof | RIGEL PHARMACEUTICALS, INC. (US) | 2025-07-15 | — | — | US | disclosed |
| US-20240382470-A1 | Irak Inhibitor for Treating Cytokine Release-Related Conditions Associated With Infection by a Respiratory Virus | RIGEL PHARMACEUTICALS INC (US) | 2024-11-21 | — | — | US | disclosed |
| CN-118510771-A | IRAK inhibitors for the treatment of conditions associated with cytokine release associated with respiratory viral infection | 里格尔药品股份有限公司 | 2024-08-16 | — | — | CN | disclosed |
| EP-4399208-A1 | IRAK INHIBITOR FOR TREATING CYTOKINE RELEASE-RELATED CONDITIONS ASSOCIATED WITH INFECTION BY A RESPIRATORY VIRUS | Rigel Pharmaceuticals, Inc. (US) | 2024-07-17 | — | — | EP | disclosed |
| US-20230399326-A1 | PYRAZOLE COMPOUNDS, FORMULATIONS THEREOF, AND A METHOD FOR USING THE COMPOUNDS AND/OR FORMULATIONS | RIGEL PHARMACEUTICALS, INC. (US) | 2023-12-14 | — | — | US | disclosed |
| WO-2023038815-A1 | IRAK INHIBITOR FOR TREATING CYTOKINE RELEASE-RELATED CONDITIONS ASSOCIATED WITH INFECTION BY A RESPIRATORY VIRUS | RIGEL PHARMACEUTICALS, INC. (US) | 2023-03-16 | — | — | WO | disclosed |
| US-20220306620-A1 | PYRAZOLE COMPOUNDS, FORMULATIONS THEREOF, AND A METHOD FOR USING THE COMPOUNDS AND/OR FORMULATIONS | RIGEL PHARMACEUTICALS, INC. (US) | 2022-09-29 | — | — | US | disclosed |
| US-20220288047-A1 | METHOD FOR TREATING A DISEASE OR CONDITION USING A PYRAZOLE COMPOUND OR FORMULATION THEREOF | RIGEL PHARMACEUTICALS, INC. (US) | 2022-09-15 | — | — | US | disclosed |
| CN-106102747-A | NO-releasing nitrooxy-chromene conjugates | 欧利瑟斯制药公司 | 2016-11-09 | — | — | CN | disclosed |
| WO-2015109014-A1 | NO-RELEASING NONOATE(OXYGEN-BOUND)CHROMENE CONJUGATES | Euclises Pharmaceuticals, Inc. (US) | 2015-07-23 | — | — | WO | disclosed |
| US-20150197500-A1 | NO-RELEASING GUANIDINE-CHROMENE CONJUGATES | EUCLISES PHARMACEUTICALS INC (US) | 2015-07-16 | — | — | US | disclosed |
| US-20020082420-A1 | Bicyclic heterocycles, pharmaceutical compositions containing them, their use, and processes for preparing them | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-06-27 | — | — | US | disclosed |
| EP-0334853-B1 | SOFT STEROIDS HAVING ANTI-INFLAMMATORY ACTIVITY | BODOR, Nicholas S. (US) | 1993-06-09 | — | — | EP | disclosed |
| EP-0334853-A4 | SOFT STEROIDS HAVING ANTI-INFLAMMATORY ACTIVITY. | BODOR NICHOLAS S | 1990-02-26 | — | — | EP | disclosed |
| EP-0334853-A1 | SOFT STEROIDS HAVING ANTI-INFLAMMATORY ACTIVITY | BODOR, Nicholas S. (US) | 1989-10-04 | — | — | EP | disclosed |
| WO-1989003390-A1 | SOFT STEROIDS HAVING ANTI-INFLAMMATORY ACTIVITY | BODOR NICHOLAS S (US) | 1989-04-20 | — | — | WO | disclosed |
| US-4710495-A | Soft steroids having anti-inflammatory activity | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1987-12-01 | — | — | US | disclosed |
| US-4388246-A | THERMAL SPLITTING OF CARBAMATES | BAYER AKTIENGESELLSCHAFT (DE) | 1983-06-14 | — | — | US | disclosed |