Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.71 |
| ▸ | HPGD | P15428 | 6/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.71 |
| ▸ | NPC1 | O15118 | 3/20 | 0.71 |
| ▸ | RAB9A | P51151 | 3/20 | 0.71 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.71 |
| ▸ | STS | P08842 | 1/20 | 0.60 |
| ▸ | CALM1 | P0DP23 | 2/20 | 0.57 |
| ▸ | PKM | P14618 | 2/20 | 0.57 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 3/20 | 0.50 |
| ▸ | MAOA | P21397 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | APP | P05067 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7575776 | 1.00 | MAPT (0.71) | MAPTHPGDALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL4987282 | 0.86 | APP (0.65) | MAPTHPGDALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL10144896 | 0.86 | APP (0.65) | MAPTHPGDALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL11560297 | 0.83 | KDM4E (0.68) | MAPTHPGDALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL11430879 | 0.83 | KDM4E (0.68) | MAPTHPGDALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL2465240 | 0.83 | HPGD (1.00) | MAPTHPGDALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL435366 | 0.83 | HPGD (1.00) | MAPTHPGDALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL10144901 | 0.83 | APP (0.67) | MAPTHPGDALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL4989024 | 0.83 | APP (0.69) | MAPTHPGDALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL4987332 | 0.83 | APP (0.67) | MAPTHPGDALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1070059-B1 | CHROMANONE AND THIOCHROMANONE DERIVATIVES | NOVARTIS AG (CH) | 2002-09-25 | — | — | EP | disclosed |
| EP-1070059-A1 | CHROMANONE AND THIOCHROMANONE DERIVATIVES | Novartis AG (CH) | 2001-01-24 | — | — | EP | disclosed |
| WO-1999052890-A1 | CHROMANONE AND THIOCHROMANONE DERIVATIVES | NOVARTIS AG (CH) | 1999-10-21 | — | — | WO | disclosed |