Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 1.00 |
| ▸ | MAPT | P10636 | 4/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 1.00 |
| ▸ | NPC1 | O15118 | 2/20 | 1.00 |
| ▸ | RAB9A | P51151 | 2/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 1.00 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.61 |
| ▸ | STS | P08842 | 1/20 | 0.60 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | GABRP | O00591 | 1/20 | 0.51 |
| ▸ | GABRD | O14764 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | TNKS | O95271 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2465240 | 1.00 | HPGD (1.00) | HPGDKDM4EMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL9975965 | 0.88 | KDM4E (0.78) | HPGDKDM4EMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL9976005 | 0.88 | KDM4E (0.78) | HPGDKDM4EMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL10615084 | 0.88 | KDM4E (0.78) | HPGDKDM4EMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL9976007 | 0.88 | KDM4E (0.78) | HPGDKDM4EMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL28245558 | 0.85 | KDM4E (0.74) | HPGDKDM4EMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL9975966 | 0.84 | KDM4E (0.72) | HPGDKDM4EMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL9976004 | 0.84 | KDM4E (0.72) | HPGDKDM4EMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL9976009 | 0.84 | KDM4E (0.72) | HPGDKDM4EMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL9975962 | 0.84 | MAPT (0.80) | HPGDKDM4EMAPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 197 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104593443-A | Preparation method of agilawood chromone component | GUANGDONG INST MICROBIOLOGY | 2015-05-06 | — | — | CN | claimed |
| CN-101525323-B | Novel styryl chromone type compound and preparation method and use thereof | CHUNHUA YANG | 2011-06-15 | — | — | CN | claimed |
| CN-101525323-A | Novel styryl chromone type compound and preparation method and use thereof | CHUNHUA YANG | 2009-09-09 | — | — | CN | claimed |
| JP-4225973-A | — | — | None | — | — | JP | disclosed |
| WO-2020193802-A1 | POLYMERIC CONJUGATES AND USES THEREOF | FUNDACIÓN DE LA COMUNIDAD VALENCIANA CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE (ES) | 2020-10-01 | — | — | WO | disclosed |
| US-20190192473-A1 | Use Of 2,5-Dihydroxybenzene Compounds And Derivatives For The Treatment Of Rosacea | AmDerma Pharmaceuticals, LLC | 2019-06-27 | — | — | US | disclosed |
| US-20190192474-A1 | Use Of 2,5-Dihydroxybenzene Compounds And Derivatives For The Treatment Of Skin Cancer | AmDerma Pharmaceuticals, LLC | 2019-06-27 | — | — | US | disclosed |
| US-10278941-B2 | Use of 2,5-dihydroxybenzene compounds and derivatives for the treatment of glioma | AmDerma Pharmaceuticals, LLC (US) | 2019-05-07 | — | — | US | disclosed |
| US-10278940-B2 | Use of 2,5-dihydroxybenzene compounds and derivatives for the treatment of skin cancer | AmDerma Pharmaceuticals, LLC (US) | 2019-05-07 | — | — | US | disclosed |
| US-20180028484-A1 | Use Of 2,5-Dihydroxybenzene Compounds And Derivatives For The Treatment Of Rosacea | AmDerma Pharmaceuticals, LLC | 2018-02-01 | — | — | US | disclosed |
| US-20170231932-A1 | METHODS OF USE FOR 2,5-DIHYDROXYBENZENE SULFONIC ACID COMPOUNDS FOR THE TREATMENT OF CANCER, ROSACEA AND PSORIASIS | AmDerma Pharmaceuticals, LLC | 2017-08-17 | — | — | US | disclosed |
| WO-2005023183-A2 | NITROSATED AD NITROSYLATED DIURETIC COMPOUDS, COMPOSITIONS AND METHODS OF USE | NITROMED, INC. (US) | 2005-03-17 | — | — | WO | disclosed |
| US-20050059655-A1 | Nitrosated and nitrosylated diuretic compounds, compositions and methods of use | NITROMED, INC. (US) | 2005-03-17 | — | — | US | disclosed |
| WO-2005018561-A2 | NITROSATED AND NITROSYLATED CARDIOVASCULAR COMPOUNDS, COMPOSITIONS AND METHODS OF USE | NITROMED, INC. (US) | 2005-03-03 | — | — | WO | disclosed |
| US-5409952-A | Anticancer agents | ADIR ET COMPAGNIE (FR) | 1995-04-25 | — | — | US | disclosed |
| US-5409952-A | Anticancer agents | ADIR ET COMPAGNIE (FR) | 1995-04-25 | — | — | US | disclosed |
| JP-H04225973-A | NOVEL HETEROCYCLIC COMPOUND, 2-STYRYL-4H-1-BENZOPYRAN-4-ONE, ITS PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING IT | ADIR | 1992-08-14 | — | — | JP | disclosed |
| EP-0454587-A1 | Heterocyclic derivatives: 2-styryl-4H-1-benzopyran-4-ons, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1991-10-30 | — | — | EP | disclosed |
| EP-0454587-A1 | Heterocyclic derivatives: 2-styryl-4H-1-benzopyran-4-ons, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1991-10-30 | — | — | EP | disclosed |
| US-RE28698-E | Electrophotographic material containing sensitizers | MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. (JA) | 1976-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190192473-A1 | Use Of 2,5-Dihydroxybenzene Compounds And Derivatives For The Treatment Of Rosacea | CYP8B1, CYP1B1, CYP26B1 | HPGD 198/4885KDM4E 2246/4885MAPT 2619/4885 |
| US-10278940-B2 | Use of 2,5-dihydroxybenzene compounds and derivatives for the treatment of skin cancer | CYP8B1, CYP26B1, CYP24A1 | HPGD 219/4885KDM4E 540/4885MAPT 3634/4885 |
| US-20170231932-A1 | METHODS OF USE FOR 2,5-DIHYDROXYBENZENE SULFONIC ACID COMPOUNDS FOR THE TREATMENT OF CANCER, ROSACEA AND PSORIASIS | IL2, IL2RA, IL5 | HPGD 2149/4885KDM4E 1383/4885MAPT 2045/4885 |
| US-20190192474-A1 | Use Of 2,5-Dihydroxybenzene Compounds And Derivatives For The Treatment Of Skin Cancer | CYP8B1, CYP26B1, CYP24A1 | HPGD 219/4885KDM4E 540/4885MAPT 3634/4885 |
| US-20050059655-A1 | Nitrosated and nitrosylated diuretic compounds, compositions and methods of use | REN, NOS1, NOS3 | HPGD 60/4885KDM4E 3048/4885MAPT 3126/4885 |
| US-20180028484-A1 | Use Of 2,5-Dihydroxybenzene Compounds And Derivatives For The Treatment Of Rosacea | CYP8B1, CYP1B1, CYP26B1 | HPGD 198/4885KDM4E 2246/4885MAPT 2619/4885 |
| US-10278941-B2 | Use of 2,5-dihydroxybenzene compounds and derivatives for the treatment of glioma | ALDH1A2, IDH3A, IDH3B | HPGD 179/4885KDM4E 1649/4885MAPT 1843/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.