Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 8/20 | 0.48 |
| ▸ | MAOA | P21397 | 7/20 | 0.48 |
| ▸ | KDM1A | O60341 | 5/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.48 |
| ▸ | CYP2B6 | P20813 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL7569185 | 0.90 | MEN1 (0.57) | HDAC4MEN1KMT2ASMN1; SMN2NPSR1 | |
| SCHEMBL2768025 | 0.89 | MAOB (0.57) | MEN1KMT2AMAOBMAOAKDM1A | |
| SCHEMBL2768026 | 0.89 | MAOB (0.57) | MEN1KMT2AMAOBMAOAKDM1A | |
| SCHEMBL2769401 | 0.89 | MAOB (0.57) | MEN1KMT2AMAOBMAOAKDM1A | |
| Cyclohexane SCHEMBL7567386 | 0.88 | MEN1 (0.60) | HDAC4MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL7575974 | 0.86 | SMN1; SMN2 (0.47) | HDAC4MEN1KMT2ASMN1; SMN2NPSR1 | |
| Ammonia Solution, Strong SCHEMBL11529212 | 0.86 | MAOB (0.55) | MEN1KMT2AMAOBMAOAKDM1A | |
| SCHEMBL1195508 | 0.83 | EDNRA (0.52) | HDAC4SMN1; SMN2NPSR1ALDH1A1HPGD | |
| SCHEMBL15590483 | 0.81 | AKR1C3 (0.55) | HDAC4SMN1; SMN2NPSR1ALDH1A1HPGD | |
| SCHEMBL1073458 | 0.81 | AKR1C3 (0.55) | HDAC4SMN1; SMN2NPSR1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0926118-B1 | Process for the purification of bisphenols and preparation of polycarbonates therefrom | GEN ELECTRIC (US) | 2002-09-11 | — | — | EP | disclosed |
| US-6008315-A | REACTING A PHENOL AND A KETONE TO FORM BISPHENOL IN SOLUTION OR A MIXED SOLUTION OF PHENOL AND BISPHENOL, AND THE IMPROVEMENT COMPRISES FILTERING IN A NONCONTAMINATING, HEAT RESISTANT, REUSABLE CALCINED METAL FILTER | GENERAL ELECTRIC COMPANY (US) | 1999-12-28 | — | — | US | disclosed |
| EP-0926118-A1 | Process for the purification of bisphenols and preparation of polycarbonates therefrom | GENERAL ELECTRIC COMPANY (US) | 1999-06-30 | — | — | EP | disclosed |