Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 17/20 | 0.74 |
| ▸ | ESR2 | Q92731 | 13/20 | 0.74 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.53 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.53 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7574747 | 0.99 | ESR1 (0.73) | ESR1ESR2PSMB1PSMB5PSMB2 | |
| SCHEMBL7580135 | 0.94 | ESR1 (0.67) | ESR1ESR2PSMB1PSMB5PSMB2 | |
| SCHEMBL7582532 | 0.93 | ESR1 (0.65) | ESR1ESR2 | |
| SCHEMBL7580940 | 0.93 | ESR1 (0.64) | ESR1ESR2PSMB1PSMB5PSMB2 | |
| SCHEMBL7573976 | 0.91 | ESR1 (0.62) | ESR1ESR2 | |
| SCHEMBL7576311 | 0.90 | ESR1 (0.61) | ESR1ESR2 | |
| SCHEMBL7574693 | 0.90 | ESR1 (0.61) | ESR1ESR2 | |
| SCHEMBL7573077 | 0.89 | ESR1 (0.60) | ESR1ESR2 | |
| SCHEMBL7581961 | 0.88 | ESR1 (0.59) | ESR1ESR2 | |
| SCHEMBL7574765 | 0.87 | ESR1 (0.57) | ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5994370-A | ESTROGEN RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 1999-11-30 | — | — | US | claimed |
| EP-0873992-B1 | Indene compounds having activity as SERMs | LILLY CO ELI (US) | 2002-09-25 | — | — | EP | disclosed |
| US-5994370-A | ESTROGEN RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 1999-11-30 | — | — | US | disclosed |
| EP-0873992-A1 | Indene compounds having activity as SERMs | ELI LILLY AND COMPANY (US) | 1998-10-28 | — | — | EP | disclosed |