Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 19/20 | 0.60 |
| ▸ | ESR2 | Q92731 | 15/20 | 0.60 |
| ▸ | MLNR | O43193 | 1/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.45 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | DRD1 | P21728 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7576311 | 0.99 | ESR1 (0.61) | ESR1ESR2MLNRABCB11NR3C1 | |
| SCHEMBL8504438 | 0.95 | ESR1 (0.55) | ESR1ESR2MLNRABCB11NR3C1 | |
| SCHEMBL7574747 | 0.90 | ESR1 (0.73) | ESR1ESR2 | |
| SCHEMBL7576301 | 0.89 | ESR1 (0.74) | ESR1ESR2 | |
| SCHEMBL7571727 | 0.89 | LTA4H (0.51) | ESR1ESR2HRH3 | |
| SCHEMBL7582532 | 0.88 | ESR1 (0.65) | ESR1ESR2 | |
| SCHEMBL7574347 | 0.88 | LTA4H (0.52) | ESR1ESR2HRH3 | |
| SCHEMBL7580135 | 0.88 | ESR1 (0.67) | ESR1ESR2 | |
| SCHEMBL7574693 | 0.87 | ESR1 (0.61) | ESR1ESR2 | |
| SCHEMBL7580940 | 0.86 | ESR1 (0.64) | ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5994370-A | ESTROGEN RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 1999-11-30 | — | — | US | claimed |
| EP-0873992-B1 | Indene compounds having activity as SERMs | LILLY CO ELI (US) | 2002-09-25 | — | — | EP | disclosed |
| US-5994370-A | ESTROGEN RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 1999-11-30 | — | — | US | disclosed |
| EP-0873992-A1 | Indene compounds having activity as SERMs | ELI LILLY AND COMPANY (US) | 1998-10-28 | — | — | EP | disclosed |