Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.57 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.57 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | SLC18A3 | Q16572 | 3/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL7572186 | 0.90 | AKR1C3 (0.70) | AKR1C3AKR1C1GRIN2BMAPTGAA | |
| SCHEMBL2766491 | 0.89 | SLC18A3 (0.52) | AKR1C3AKR1C1MAPTGAASLC18A3 | |
| SCHEMBL11661537 | 0.89 | SLC18A3 (0.52) | AKR1C3AKR1C1MAPTGAASLC18A3 | |
| SCHEMBL7576366 | 0.86 | AKR1C3 (0.55) | AKR1C3AKR1C1GRIN2BMAPTGAA | |
| Bicarbonate SCHEMBL7568966 | 0.86 | AKR1C3 (0.60) | AKR1C3AKR1C1SLC18A3 | |
| Bicarbonate SCHEMBL1720488 | 0.84 | AKR1C3 (0.63) | AKR1C3AKR1C1GRIN2BMAPTGAA | |
| Bicarbonate SCHEMBL7573346 | 0.84 | AKR1C3 (0.63) | AKR1C3AKR1C1GRIN2BMAPTGAA | |
| SCHEMBL11665023 | 0.83 | AKR1C3 (0.74) | AKR1C3AKR1C1GRIN2BMAPTGAA | |
| SCHEMBL7388336 | 0.83 | AKR1C3 (0.74) | AKR1C3AKR1C1GRIN2BMAPTGAA | |
| SCHEMBL717453 | 0.83 | AKR1C3 (0.74) | AKR1C3AKR1C1GRIN2BMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0926118-B1 | Process for the purification of bisphenols and preparation of polycarbonates therefrom | GEN ELECTRIC (US) | 2002-09-11 | — | — | EP | disclosed |
| US-6008315-A | REACTING A PHENOL AND A KETONE TO FORM BISPHENOL IN SOLUTION OR A MIXED SOLUTION OF PHENOL AND BISPHENOL, AND THE IMPROVEMENT COMPRISES FILTERING IN A NONCONTAMINATING, HEAT RESISTANT, REUSABLE CALCINED METAL FILTER | GENERAL ELECTRIC COMPANY (US) | 1999-12-28 | — | — | US | disclosed |
| EP-0926118-A1 | Process for the purification of bisphenols and preparation of polycarbonates therefrom | GENERAL ELECTRIC COMPANY (US) | 1999-06-30 | — | — | EP | disclosed |