SCHEMBL7576403

SCHEMBL7576403

CNCCCOc1cccc([N+](=O)[O-])c1.O=[N+]([O-])c1cccc(OCCCCl)c1

nearest known ligand 0.58

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 1/20 0.58
CHRNA4 P43681 1/20 0.58
ALDH1A1 P00352 3/20 0.52
HPGD P15428 2/20 0.49
MAPT P10636 2/20 0.49
KDM4E B2RXH2 2/20 0.49
HTR1B P28222 1/20 0.49
LMNA P02545 1/20 0.48
NSD2 O96028 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
DRD2 P14416 1/20 0.48
DRD4 P21917 1/20 0.48
DRD3 P35462 1/20 0.48
MEN1 O00255 4/20 0.47
KMT2A Q03164 4/20 0.47
L3MBTL1 Q9Y468 2/20 0.47
CHRNB4 P30926 1/20 0.44
CHRNA3 P32297 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7099639 0.95 CHRNB2 (0.63) CHRNB2CHRNA4ALDH1A1HPGDMAPT
SCHEMBL16580896 0.90 CHRNB2 (0.65) CHRNB2CHRNA4ALDH1A1HPGDMAPT
SCHEMBL3975841 0.89 CHRNB2 (0.66) CHRNB2CHRNA4ALDH1A1HPGDMAPT
SCHEMBL28505899 0.84 CHRNB2 (0.64) CHRNB2CHRNA4ALDH1A1HPGDMAPT
SCHEMBL3442965 0.83 CHRNB2 (0.66) CHRNB2CHRNA4ALDH1A1HPGDMAPT
SCHEMBL14028449 0.80 CHRNB2 (0.69) CHRNB2CHRNA4ALDH1A1HPGDMAPT
SCHEMBL15498199 0.80 CHRNB2 (0.73) CHRNB2CHRNA4ALDH1A1HPGDMAPT
SCHEMBL20303777 0.80 CHRNB2 (0.55) CHRNB2CHRNA4ALDH1A1HPGDMAPT
SCHEMBL17905717 0.79 CHRNB2 (0.68) CHRNB2CHRNA4ALDH1A1HPGDMAPT
SCHEMBL11307294 0.79 CHRNB2 (0.64) CHRNB2CHRNA4ALDH1A1HPGDMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1185513-A2 ARYL SUBSTITUTED ALKYLAMINES CAPABLE OF ACTIVATING NICOTINIC CHOLINERGIC RECEPTORS Targacept, Inc. (US) 2002-03-13 EP disclosed
WO-2000071520-A2 ARYL SUBSTITUTED ALKYLAMINES CAPABLE OF ACTIVATING NICOTINIC CHOLINERGIC RECEPTORS TARGACEPT, INC. (US) 2000-11-30 WO disclosed