Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | CDC25A | P30304 | 1/20 | 0.42 |
| ▸ | CDC25B | P30305 | 1/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27845629 | 0.75 | PLK1 (0.41) | PLK1MAPTKMT2AMEN1HPGD | |
| SCHEMBL28698373 | 0.75 | PLK1 (0.41) | PLK1MAPTKMT2AMEN1HPGD | |
| SCHEMBL27848261 | 0.73 | MAPT (0.46) | PLK1MAPTKMT2AMEN1HPGD | |
| SCHEMBL6651141 | 0.72 | MAPT (0.38) | MAPTKMT2AMEN1HPGDL3MBTL1 | |
| SCHEMBL18229432 | 0.72 | MAPT (0.45) | MAPTKMT2AMEN1HPGDL3MBTL1 | |
| SCHEMBL5812357 | 0.69 | MAPT (0.36) | MAPTKMT2AMEN1L3MBTL1TDP1 | |
| SCHEMBL29520772 | 0.68 | MAPT (0.47) | PLK1MAPTKMT2AMEN1HPGD | |
| SCHEMBL18481549 | 0.67 | MAPT (0.46) | PLK1MAPTKMT2AMEN1HPGD | |
| SCHEMBL4541307 | 0.66 | CYP19A1 (0.62) | MAPTKMT2AMEN1HPGDL3MBTL1 | |
| SCHEMBL2730790 | 0.66 | ALDH1A1 (0.50) | MAPTKMT2AMEN1HPGDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002102301-A2 | SUBSTITUTED INDOLE-2-CARBOXYLIC ACID BENZYLIDENE-HYDRAZIDES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | CYTOVIA, INC. (US) | 2002-12-27 | — | — | WO | disclosed |