Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.44 |
| ▸ | PNMT | P11086 | 2/20 | 0.36 |
| ▸ | PARP1 | P09874 | 4/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
| ▸ | MGMT | P16455 | 1/20 | 0.35 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.35 |
| ▸ | ASH1L | Q9NR48 | 1/20 | 0.33 |
| ▸ | AKT2 | P31751 | 1/20 | 0.33 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HTR3B | O95264 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3068246 | 0.85 | TAAR1 (0.41) | PARP1SMN1; SMN2AKT2MAPT | |
| SCHEMBL2501354 | 0.81 | PARP1 (0.40) | PARP1PDPK1CA12ALOX15SMN1; SMN2 | |
| SCHEMBL1647059 | 0.81 | PARP1 (0.36) | PARP1PDPK1CA12ALOX15SMN1; SMN2 | |
| SCHEMBL7346990 | 0.81 | PARP1 (0.43) | PARP1PDPK1CA12ALOX15SMN1; SMN2 | |
| SCHEMBL30198124 | 0.79 | PARP1 (0.35) | PARP1PDPK1CA12ALOX15SMN1; SMN2 | |
| SCHEMBL2498957 | 0.78 | MEN1 (0.39) | PARP1PDPK1CA12ALOX15SMN1; SMN2 | |
| SCHEMBL7856465 | 0.78 | JAK2 (0.36) | PARP1PDPK1CA12ALOX15SMN1; SMN2 | |
| SCHEMBL20988851 | 0.77 | PARP1 (0.37) | PARP1PDPK1CA12ALOX15SMN1; SMN2 | |
| SCHEMBL20354325 | 0.77 | GABRA1 (0.44) | PARP1PDPK1CA12ALOX15SMN1; SMN2 | |
| SCHEMBL21895449 | 0.75 | PARP1 (0.58) | LOXL2PARP1PDPK1CA12ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1250326-A2 | INDAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND THEIR USE FOR MEDIATING OR INHIBITING CELL PROLIFERATION | AGOURON PHARMACEUTICALS, INC. (US) | 2002-10-23 | — | — | EP | disclosed |
| WO-2001053268-A2 | INDAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND THEIR USE FOR MEDIATING OR INHIBITING CELL PROLIFERATION | AGOURON PHARMACEUTICALS, INC. (US) | 2001-07-26 | — | — | WO | disclosed |